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Propiverine hydrochloride
CAS No. 54556-98-8
Propiverine hydrochloride( —— )
Catalog No. M19811 CAS No. 54556-98-8
Propiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
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| 50MG | 31 | In Stock |
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| 100MG | 48 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePropiverine hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionPropiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB).
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DescriptionPropiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB).(In Vitro):Propiverine (10-3000 nM) inhibits the speci c binding of [3H]NMS, with Kis of 339, 193 and 497 nM in the bladder, submaxillary gland and heart of mice respectively.(In Vivo):Propiverine (0.5 mg/day; p.o. once daily for 2 weeks) significantly increases UBP and LPP during passive intravesical pressure elevation, and also increases plasma norepinephrine and epinephrine levelsin rats.Propiverine (0.01-1 mg/kg; i.v.) decreases the UBP and totally suppresses the sneeze reflex at the dose of 1 mg/kg in vivo.
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In VitroPropiverine (10-3000 nM) inhibits the speci?c binding of [3H]NMS, with Kis of 339, 193 and 497 nM in the bladder, submaxillary gland and heart of mice respectively.
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In VivoPropiverine (0.5 mg/day; p.o. once daily for 2 weeks) significantly increases UBP and LPP during passive intravesical pressure elevation, and also increases plasma norepinephrine and epinephrine levelsin rats.Propiverine (0.01-1 mg/kg; i.v.) decreases the UBP and totally suppresses the sneeze reflex at the dose of 1 mg/kg in vivo. Animal Model:Female adult Sprague-Dawley rats (250-270 g)Dosage:5 mg dissolved in distilled water (0.5 mL)Administration: P.o. once daily for 2 weeks Result:Increased urethral baseline pressure (UBP) and leak-point pressure (LPP) significantly.Increased plasma epinephrine and norepinephrine levels.No significant changes were observed in body weight.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research AreaNeurological Disease
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IndicationOveractive bladder; Urinary incontinence
Chemical Information
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CAS Number54556-98-8
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Formula Weight403.94
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Molecular FormulaC23H30ClNO3
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Purity>98% (HPLC)
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SolubilityDMSO:198 mM
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SMILESCl.CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Urantide
Selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-induced relaxation. Behaves as a partial agonist in a calcium mobilization assay (in CHO cells expressing hUT receptors).
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Chlorindanol
Chlorindanol is a new antiseptic agent.
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Methyl retinoate
Methyl retinoate (Retinoic acid, methyl ester) induces aseptic inflammation at the site of administration in in vivo experiments, which causes an increase in the number of leukocytes in the blood and a decrease in the levels of red blood cells and Hb.Methyl retinoate promotes spontaneous leukemia.Methyl retinoate can be Used in the treatment of gastric hypertrophy and ulcers due to vitamin A deficiency.
