Cefamandole nafate

Research use only, not for human use.

Cefamandole nafate is a second-generation broad-spectrum cephalosporin antibiotic.

Cefamandole nafate is a second-generation broad-spectrum cephalosporin antibiotic.(In Vitro):Cefamandole nafate is shown to be rapidly converted to cefamandole in bacteriological media, with a half-life of less than 1 h at a pH of 7.0 or above. At pH 6.0, in log-phase inhibition experiments, however, Cefamandole nafate is more stable, allowing delineation of the activity between cefamandole and cefamandole nafate.(In Vivo):The toxicity of Cefamandole nafate administered iv Is studied in rats receiving doses of 250-1,000 mg/kgfive days per week for one month.After the administration of Cefamandole nafate for one month, there are no treatment-related adverse effects on growth, food consumption, clinical chemistry, hematology, or organ weights.

Cefamandole nafate is shown to be rapidly converted to cefamandole in bacteriological media, with a half-life of less than 1 h at a pH of 7.0 or above. At pH 6.0, in log-phase inhibition experiments, however, Cefamandole nafate is more stable, allowing delineation of the activity between cefamandole and cefamandole nafate.

The toxicity of Cefamandole nafate administered iv Is studied in rats receiving doses of 250-1,000 mg/kg five days per week for one month.After the administration of Cefamandole nafate for one month, there are no treatment-related adverse effects on growth, food consumption, clinical chemistry, hematology, or organ weights.

Cephamandole nafate | Cefamandole formate sodium

GPCR/G Protein

Antibacterial

Bacterial

Inflammation/Immunology

Pulmonary infection urinary tract infection biliary tract infection skin and soft tissue infection bone and joint infection

42540-40-9

512.49

C19H17N6NaO6S2

>98% (HPLC)

DMSO: ≥ 41 mg/mL (80.00 mM);Water:≥ 29 mg/mL (56.59 mM)

[Na+].Cn1nnnc1SCC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](OC=O)c1ccccc1)C2=O)C([O-])=O

sodium;(6R7R)-7-[[(2R)-2-formyloxy-2-phenylacetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

(-20℃)

With Ice Pack

≥ 2 years