2-Picolinic acid

Research use only, not for human use.

PCL 016 is a topical antiviral agent which inhibits adenovirus replication in rabbit.

PCL 016 is a topical antiviral agent which inhibits adenovirus replication in rabbit.(In Vivo):Topical 1.5% PCL, 0.8% PCL, 0.369% PCL (pH7), 0.369% PCL (pH4) and 0.5% CDV are significantly more effective than the Control in reducing Ad Positive Cultures/Total (Days 1-14) and the Duration of Ad Shedding in the Ad5/NZW rabbit ocular model. Although not statistically significant, there appears to be a trend toward concentration-dependent efficacy of Picolinic acid on the Duration of Ad Shedding. There is no apparent ocular toxicity associated with Picolinic acid concentrations.

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Topical 1.5% PCL, 0.8% PCL, 0.369% PCL (pH7), 0.369% PCL (pH4) and 0.5% CDV are significantly more effective than the Control in reducing Ad Positive Cultures/Total (Days 1-14) and the Duration of Ad Shedding in the Ad5/NZW rabbit ocular model. Although not statistically significant, there appears to be a trend toward concentration-dependent efficacy of Picolinic acid on the Duration of Ad Shedding. There is no apparent ocular toxicity associated with Picolinic acid concentrations.

PCL 016

Proteasome/Ubiquitin

Endogenous Metabolite

Endogenous Metabolite

Endocrinology

Acne

98-98-6

123.11

C6H5NO2

>98% (HPLC)

DMSO:10 mM;Water:50 mg/mL

OC(=O)c1ccccn1

2-Pyridinecarboxylic acid

(-20℃)

With Ice Pack

≥ 2 years