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S3QEL-2
CAS No. 890888-12-7
S3QEL-2( —— )
Catalog No. M34135 CAS No. 890888-12-7
S3QEL-2 is a selective complex III superoxide-producing site inhibitor with neuroprotective effects that inhibits PC-3 cell proliferation in pyruvate-starved medium in a dose-dependent manner.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 63 | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameS3QEL-2
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NoteResearch use only, not for human use.
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Brief DescriptionS3QEL-2 is a selective complex III superoxide-producing site inhibitor with neuroprotective effects that inhibits PC-3 cell proliferation in pyruvate-starved medium in a dose-dependent manner.
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DescriptionS3QEL-2, a suppressor of superoxide production from mitochondrial complex III, potently and selectively suppresses site IIIQo superoxide production (IC50=1.7 μM). S3QEL-2 does not affect oxidative phosphorylation, and normal electron flux. S3QEL-2 inhibits HIF-1α accumulation.
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In VitroS3QELs-2 protects against ROS-induced, JNK-mediated cell stress in pancreatic β-cells and S3QEL-2 strongly mitigates the oxidative stress-induced apoptosis that limits the yield of functional β-cells from intact islets.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorMitochondrial Metabolism
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Research Area——
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Indication——
Chemical Information
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CAS Number890888-12-7
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Formula Weight323.44
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Molecular FormulaC19H25N5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (154.59 mM; Ultrasonic )
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SMILESN=1C=NC(=C2C=NN(C12)C3=CC=C(C(=C3)C)C)N(CCC)CCC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Orr AL, et al. Suppressors of superoxide production from mitochondrial complex III. Nat Chem Biol. 2015;11(11):834-836.?
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