Robinin

Research use only, not for human use.

Robinin is a flavone glycoside based on kaempferol.

Robinin is a flavone glycoside based on kaempferol.

Western Blot Analysis Cell Line:hPBMCs Concentration:6 μg/mL Incubation Time:24 h Result:Inhibited the upregulated expression of MCP 1, TNF-α, IL-6 and ICAM-1 with anti-inflammatory properties.Cell Viability Assay Cell Line: hPBMCs Concentration:1 μg/mL, 2 μg/mL,4 μg/mL,6 μg/mL,8 μg/mL,10 μg/mLIncubation Time:24 h Result:Concentration from 1 μg/ml-10 μg/ml on hPBMCs had no obvious cytotoxicity.RT-PCR Cell Line:hPBMCs Concentration:1 μg/mL, 2 μg/mL,4 μg/mL,6 μg/mL,8 μg/mL,10 μg/mL Incubation Time:24 h Result:Inhibited the upregulated expression of TLR2 and TLR4.Cell Proliferation Assay Cell Line:Mia-PACA2 and PANC-1 Concentration:1 μM Incubation Time:24 h Result:Inhibited cell proliferation.Cell Migration Assay Cell Line:Mia-PACA2 and PANC-1 Concentration:1 μM Incubation Time:24 h Result:Decreased the cell migration area

Animal Model:Adjuvant arthritis mice model Dosage:50 mg/kg Robinin and 0.3 mg/kg MTX twice a week Administration:Oral gavage (p.o.)Result:Had anti-inflammatory and anti-arthritic action.Animal Model:Sprague Dawley rats model Dosage:50 mg/kg Robinin for 10 days Administration:Oral gavage (p.o.)Result:Reduced the cardiotoxic effects of Doxorubicin-induced

EINECS 206-113-3 | NSC 9222 | Robinin

Others

Other Targets

Others

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301-19-9

740.66

C33H40O19

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (337.54 mM)

C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@@H]([C@@H]([C@H]([C@@H](O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)O)O)O)C6=CC=C(C=C6)O)O)O)O)O)O)O

3-((6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-galactopyranosyl)oxy)-7-((6-deoxy-alpha-L-mannopyranosyl)oxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

(-20℃)

With Ice Pack

≥ 2 years