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K 0859

CAS No. 890129-26-7

K 0859( NVP-BGG463 )

Catalog No. M19234 CAS No. 890129-26-7

BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	148	In Stock
2MG	75	In Stock
5MG	116	In Stock
10MG	188	In Stock
25MG	351	In Stock
50MG	494	In Stock
100MG	714	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

K 0859
Note

Research use only, not for human use.
Brief Description

BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.
Description

NVP-BGG463 is a novel Type II kinase inhibitor, targeting CDK2.
In Vitro

BGG463 potently inhibits T315I BCR–ABL autophosphorylation and shows good oral efficacy in mouse models of CML.
In Vivo

——
Synonyms

NVP-BGG463
Pathway

Membrane Transporter/Ion Channel
Target

TRP/TRPV Channel
Recptor

c-ABL-T334I|Abl|Abl (T315I)
Research Area

——
Indication

——

Chemical Information

CAS Number

890129-26-7
Formula Weight

578.6
Molecular Formula

C30H29F3N6O3
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 125 mg/mL; 216.05 mM
SMILES

CC(=O)Nc1cc(ncn1)Oc2ccc3c(c2)cccc3C(=O)Nc5ccc(CN4CCN(C)CC4)c(c5)C(F)(F)F
Chemical Name

6-(6-Acetylamino-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid [4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-amide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

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