K 0859

CAS No. 890129-26-7

K 0859( NVP-BGG463 )

Catalog No. M19234 CAS No. 890129-26-7

BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 148 In Stock
2MG 75 In Stock
5MG 116 In Stock
10MG 188 In Stock
25MG 351 In Stock
50MG 494 In Stock
100MG 714 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    K 0859
  • Note
    Research use only, not for human use.
  • Brief Description
    BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.
  • Description
    NVP-BGG463 is a novel Type II kinase inhibitor, targeting CDK2.
  • In Vitro
    BGG463 potently inhibits T315I BCR–ABL autophosphorylation and shows good oral efficacy in mouse models of CML.
  • In Vivo
    ——
  • Synonyms
    NVP-BGG463
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    c-ABL-T334I|Abl|Abl (T315I)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    890129-26-7
  • Formula Weight
    578.6
  • Molecular Formula
    C30H29F3N6O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 125 mg/mL; 216.05 mM
  • SMILES
    CC(=O)Nc1cc(ncn1)Oc2ccc3c(c2)cccc3C(=O)Nc5ccc(CN4CCN(C)CC4)c(c5)C(F)(F)F
  • Chemical Name
    6-(6-Acetylamino-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid [4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-amide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
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