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USP8-IN-22e

CAS No. 924296-19-5

USP8-IN-22e( —— )

Catalog No. M16623 CAS No. 924296-19-5

A potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.28 uM.

Purity : >98% (HPLC)

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Biological Information

Product Name

USP8-IN-22e
Note

Research use only, not for human use.
Brief Description

A potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.28 uM.
Description

A potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.28 uM; shows no inhibitory activity for USP7 (IC50>100 uM).
In Vitro

DUBs-IN-2 (compound 22 e) is a potent USP8 inhibitor with an IC50 of 0.28 μM, and has no effect on USP7, with an IC50 of >100 μM. DUBs-IN-2 inhibits the viability of HCT116 colon cell line and PC-3 prostate cancer cell line with IC50 values of 0.5-1.5μM.
In Vivo

——
Synonyms

——
Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

DUB
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

924296-19-5
Formula Weight

275.2649
Molecular Formula

C15H9N5O
Purity

>98% (HPLC)
Solubility

DMSO: 9.06 mg/mL
SMILES

CCON=C1C2=CC=CC=C2C3=NC(=C(N=C31)C#N)C#N
Chemical Name

9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-(ethoxyimino)-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Colombo M, et al. ChemMedChem. 2010 Apr 6;5(4):552-8.

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