HC-067047

Research use only, not for human use.

HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .

HC-067047 is a potent and selective TRPV4 antagonist. HC-067047 increases functional bladder capacity and reduces micturition frequency in WT mice and rats with cystitis. HC-067047 did not affect bladder function in Trpv4(-/-) mice, demonstrating that its in vivo effects are on target. HC-067047 may provide a promising means of treating bladder

HC-067047 (1 μM; 24 hours; HEI-OC1 cells) treatment significantly decreases mRNA expression in high glucose cultured HEI-OC1 cells.?HC-067047 (1 μM; 24 hours; HEI-OC1 cells) treatment significantly decreases the expression of TRPV4 protein.HC-067047 (1 μM; 48 hours; HEI-OC1 cells) treatment inhibits cell proliferation.HC-067047 (1 μM; 48 hours; HEI-OC1 cells) treatment promotes cell apoptosis. RT-PCR Cell Line:HEI-OC1 cells Concentration:1 μM Incubation Time:24 hours Result:The mRNA expression was significantly decreased.Western Blot Analysis Cell Line:HEI-OC1 cells Concentration:1 μM Incubation Time:24 hours Result:The expression of TRPV4 protein was significantly decreased.Cell Proliferation Assay Cell Line:HEI-OC1 cells Concentration:1 μM Incubation Time:48 hours Result:Inhibited cell proliferation.Apoptosis Analysis Cell Line:HEI-OC1 cells Concentration:1 μM Incubation Time:48 hoursResult:Promoted cell apoptosis.

Animal Model:Cyclophosphamide-treated WT and Trpv4?/? mice, and naive WT miceDosage:0 mg/kg, 1 mg/kg, 10 mg/kg, 50 mg/kg Administration:Intraperitoneal injection; for 30 minutes Result:Increased functional bladder capacity and reduces micturition frequency in WT mice with cystitis and did not affect bladder function in Trpv4?/? mice.

HC-067047 | HC 067047 | HC067047

Others

Other Targets

hTRPV4/mTRPV4

Cancer

——

883031-03-6

471.51

C26H28F3N3O2

>98% (HPLC)

DMSO : 50 mg/mL 106.04 mM

FC(F)(F)c1cc(ccc1)NC(=O)c4cc(c2ccccc2)n(CCCN3CCOCC3)c4C

2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide

(-20℃)

With Ice Pack

≥ 2 years