AKBA( AKBA | 3-O-acetyl-11-keto-β-Boswellic acid )

Catalog No. M18980 CAS No. 67416-61-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

AKBA
Note

Research use only, not for human use.
Brief Description

3-O-Acetyl-11-keto-beta-boswellic acid inhibits 5-lipoxygenase product formation with an IC(5) of 1.5 m muM.
Description

AKBA is an antiangiogenic and neuroprotective agent, reducing the impact of proliferative retinopathies, protecting neurons against ischemic injury involving the Nrf2/HO-1 pathway. It selectively inhibits 5-lipoxygenase (IC50 = 1.5 μM) in an enzyme-directed, nonredox, and noncompetitive manner.2 3-acetyl-11-keto-β-Boswellic acid and other members of the boswellic acid family have been studied for potential use in the control of inflammatory diseases, including arthritis and cancer.
In Vitro

——
In Vivo

——
Synonyms

AKBA | 3-O-acetyl-11-keto-β-Boswellic acid
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Cancer
Indication

——

CAS Number

67416-61-9
Formula Weight

512.73
Molecular Formula

C32H48O5
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 5.2 mg/mL; 10.14 mM
SMILES

CC1CCC2(CCC3(C(=CC(=O)C4C3(CCC5C4(CCC(C5(C)C(=O)O)OC(=O)C)C)C)C2C1C)C)C
Chemical Name

(3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bS)-3-acetyloxy-4,6a,6b,8a,11,12,14b-heptamethyl-14-oxo-1,2,3,4a,5,6,7,8,9,10,11,12,12a,14a-tetradecahydropicene-4-carboxylic acid