Cardiogenol C hydrochloride

Research use only, not for human use.

Cardiogenol C hydrochloride is a cardiomyogenesis inducer in embryonic stem cells.

Cardiogenol C hydrochloride is a cardiomyogenesis inducer in embryonic stem cells.

Cardiogenol C (1 μM; 7 days) has a cardiomyogenic effect on P19 cells, it significantly increases atrial natriuretic factor (ANF,?nppa) in P19 cells when it compares to untreated control cells.Cardiogenol C (0.01-100 μM; 7 days) significantly increases ANF expression. In addition, another frequently used cardiac marker gene (NKX2-5) is also significantly increased by this small molecule in C2C12 cells.Cardiogenol C (0.001-100 μM; 7 days) increases cardiac Nav1.5 sodium channel protein expression as dose-dependent manner in C2C12 cells.Cardiogenol C (0.01-100 μM; 7 days) does not effect cell growth even at 10 μM. In addition, Cardiogenol C either solves in water or DMSO generates a similar effect. The highest concentration, 100 μM has significant cellular toxicity on C2C12 cells. RT-PCRCell Line:C2C12 cells Concentration:0.01 μM; 0.1 μM; 1 μM; 3 μM; 10 μM; 30 μM; 100 μM Incubation Time:7 days Result:Increases ANF and NKX2.5 mRNA level as a dose-dependent manner. Western Blot Analysis Cell Line:C2C12 cells Concentration:0.001 μM; 0.01 μM; 0.1 μM; 1 μM; 10 μM Incubation Time:7 days Result:Increased cardiac Nav1.5 sodium channel protein levels.Cell Proliferation Assay Cell Line:C2C12 cells Concentration:0.01 μM; 0.1 μM; 1 μM Incubation Time:7 days Result:Did not exert toxic effects on C2C12 cells at 0.01-10 μM treatment.

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GPCR/G Protein

Cannabinoid Receptor

Others

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671225-39-1

296.75

C13H17ClN4O2

>98% (HPLC)

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Cl.COC1=CC=C(NC2=NC=CC(NCCO)=N2)C=C1

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(-20℃)

With Ice Pack

≥ 2 years