Quinine HCl Dihydrate( —— )

Catalog No. M18893 CAS No. 6119-47-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Quinine HCl Dihydrate
Note

Research use only, not for human use.
Brief Description

Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.
Description

Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.
In Vitro

Cell Proliferation Assay Cell Line:Human hepatocarcinoma cell line(HepG2) Concentration:150 μM Incubation Time:30 min Result:Inhibited DENV virus replication with 19% yield compared to untreated. Reduced DENV-positive cells from 23.28% to 12.05% in a dose-dependent manner.
In Vivo

Animal Model:Swiss albino mice 7-8-weeks (weighing 24 g) Dosage:Swiss albino mice 7-8-weeks (weighing 24 g) Administration:Oral gavage; every week; 16 weeks Result:Resulted in a significant reduction in tumor size and weight at 12 mg/kg and little effect at higher dose of 15 mg/kg.
Synonyms

——
Pathway

GPCR/G Protein
Target

SGLT
Recptor

Potassium channel
Research Area

Infection
Indication

——

CAS Number

6119-47-7
Formula Weight

396.91
Molecular Formula

C20H24N2O2·HCl·2H2O
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 100 mg/mL 251.95 mM H2O : 20 mg/mL50.39 mM;
SMILES

O.O.Cl.[H][C@@]12CCN(C[C@@H]1C=C)[C@@]([H])(C2)[C@H](O)C1=CC=NC2=C1C=C(OC)C=C2
Chemical Name

——

1. Srinivas M, et al. Proc Natl Acad Sci U S A,2001, 98(19), 10942-10947.

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