Carnosol

Research use only, not for human use.

Carnosol has anti-oxidative, anti-inflammatory, antiproliferative and apoptosis inducing properties.

Carnosol has anti-oxidative, anti-inflammatory, antiproliferative and apoptosis inducing properties. Carnosol enhances the sensitivity of chemoresistant cancer cells to chemotherapeutic agents. Carnosol may as a novel agonist of TRPA1 with an EC5 value of 12.46 µM.

It is showed that carnosol has no cytotoxic effects on GES1 cells and 10 μM carnosol strongly suppresses RSK2 activity, but has little effect on any other kinase. Carnosol exerts strong dose-dependent inhibitory effects against RSK2 autophosphorylation and phosphorylation of its substrate ATF1.

Results indicate that Carnosol significantly decreaseS the volume and weight of gastric tumors relative to the vehicle-treated group. Additionally, mice tolerate treatment with carnosol without significant loss of body weight similar to the vehicle-treated group. The phosphorylation of CREB, a direct downstream protein of RSK2, Is strongly inhibited in the carnosol-treated group but the expression of total CREB is relatively unchanged.

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Others

Other Targets

Others

Cancer|Inflammation/Immunology

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5957-80-2

330.42

C20H26O4

>98% (HPLC)

DMSO : ≥ 125 mg/mL; 378.31 mM

CC(C)C1=C(C(=C2C(=C1)C3CC4C2(CCCC4(C)C)C(=O)O3)O)O

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(-20℃)

With Ice Pack

≥ 2 years