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Carnosol
CAS No. 5957-80-2
Carnosol( —— )
Catalog No. M18868 CAS No. 5957-80-2
Carnosol has anti-oxidative, anti-inflammatory, antiproliferative and apoptosis inducing properties.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 35 | In Stock |
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| 10MG | 50 | In Stock |
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| 25MG | 102 | In Stock |
|
| 50MG | 151 | In Stock |
|
| 100MG | 224 | In Stock |
|
| 500MG | 552 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCarnosol
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NoteResearch use only, not for human use.
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Brief DescriptionCarnosol has anti-oxidative, anti-inflammatory, antiproliferative and apoptosis inducing properties.
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DescriptionCarnosol has anti-oxidative, anti-inflammatory, antiproliferative and apoptosis inducing properties. Carnosol enhances the sensitivity of chemoresistant cancer cells to chemotherapeutic agents. Carnosol may as a novel agonist of TRPA1 with an EC5 value of 12.46 µM.
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In VitroIt is showed that carnosol has no cytotoxic effects on GES1 cells and 10 μM carnosol strongly suppresses RSK2 activity, but has little effect on any other kinase. Carnosol exerts strong dose-dependent inhibitory effects against RSK2 autophosphorylation and phosphorylation of its substrate ATF1.
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In VivoResults indicate that Carnosol significantly decreaseS the volume and weight of gastric tumors relative to the vehicle-treated group. Additionally, mice tolerate treatment with carnosol without significant loss of body weight similar to the vehicle-treated group. The phosphorylation of CREB, a direct downstream protein of RSK2, Is strongly inhibited in the carnosol-treated group but the expression of total CREB is relatively unchanged.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research AreaCancer|Inflammation/Immunology
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Indication——
Chemical Information
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CAS Number5957-80-2
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Formula Weight330.42
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Molecular FormulaC20H26O4
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 125 mg/mL; 378.31 mM
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SMILESCC(C)C1=C(C(=C2C(=C1)C3CC4C2(CCCC4(C)C)C(=O)O3)O)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Phenazoline
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Methyl retinoate
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