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Cyclizine dihydrochloride
CAS No. 5897-18-7
Cyclizine dihydrochloride( —— )
Catalog No. M18859 CAS No. 5897-18-7
Cyclizine Dihydrochloride is a histamine H1 antagonist. It is given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 45 | In Stock |
|
| 50MG | 59 | In Stock |
|
| 100MG | 106 | In Stock |
|
| 200MG | 193 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCyclizine dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionCyclizine Dihydrochloride is a histamine H1 antagonist. It is given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness.
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DescriptionCyclizine Dihydrochloride is a histamine H1 antagonist. It is given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness.
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In VitroCyclizine (100 μM) dihydrochloride significantly inhibits nitrite accumulation and iNOS protein levels in the LPS-stimulated in RAW 264.7 cells supernatants.Cyclizine dihydrochloride inhibits anti-IgE-induced histamine release from isolated human lung fragments, with an IC50 of 5.42 μM.
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In VivoCyclizine (1, 10 mg/kg) dihydrochloride enhances locomotor activity of mice in a dose-dependent manner. Animal Model:Naive male CDI mice (Charles River) weighing 25-30 g Dosage:1, 10 mg/kg Administration:s.c.; locomotor activity (crossings) measured every 15 min for 2 hr.Result:Enhanced locomotor activity in a dose-dependent manner.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorH1 receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number5897-18-7
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Formula Weight339.3
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Molecular FormulaC18H24Cl2N2
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Purity>98% (HPLC)
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Solubility——
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SMILESCN1CCN(CC1)C(c1ccccc1)c1ccccc1.Cl.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Vella-Brincat JW, et al. J Pain Symptom Manage. 2012 Mar;43(3):540-8.
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