Costunolide

Research use only, not for human use.

Costunolide has anti-inflammatory and anti-oxidant properties and mediates apoptosis.

Costunolide, also known as (+)-Costunolide, CCRIS 6754 and NSC 106404, is a naturally occurring sesquiterpene lactone, first isolated in Saussurea costus roots in 1960. It is also found in lettuce. Costunolide has been reported for the wide spectrum of biological effects, including anti-inflammatory, anticancer, antiviral, antimicrobial, antifungal, antioxidant, antidiabetic, antiulcer, and anthelmintic activities. In recent years, it have caused extensive interest in researchers due to its potential anti-cancer activities for various types of cancer, and their anti-cancer mechanisms, including causing cell cycle arrest, inducing apoptosis and differentiation, promoting the aggregation of microtubule protein, inhibiting the activity of telomerase, inhibiting metastasis and invasion, reversing multidrug resistance, restraining angiogenesis has been studied.

Cell Viability Assay Cell Line:H1299 cells Concentration:6.7 μM, 13.5 μM, 26.9 μM, 107.6 μM, 215.2 μM Incubation Time:24 hours Result:Inhibited the viability of H1299 cells (MTT assay).Apoptosis Analysis Cell Line:H1299 cells Concentration:0 μM, 12.0 μM, 24.0 μM, 48.0 μM Incubation Time:48 hours Result:Significantly promoted apoptosis at 24.0 μM and 48.0 μM.RT-PCR Cell Line:H1299 cells Concentration:0 μM, 12.0 μM, 24.0 μM, 48.0 μM Incubation Time:6 hours, 12 hours Result:Regulated the metastasis- and proliferation-associated mRNA levels in a dose-dependent manner.Western Blot Analysis Cell Line:H1299 cells Concentration:0 μM, 12.0 μM, 24.0 μM, 48.0 μM Incubation Time:48 hours Result:Significantly inhibited the EMT of H1299 cells.

Animal Model:4 weeks old female BALB/c nude mice, MDA-MB-231 cells xenograft mouse models Dosage:20?mg/kg Administration:Intraperitoneal injection, daily, for 30 days Result:Reduced the expression levels of c-Myc and p-AKT and elevated the expression levels of p53 and p-14-3-3.

CCRIS 6754 | NSC 106404 | Costus lactone | (+)-Costunolide

Others

Other Targets

FPTase| Telomerase (MCF-7)| Telomerase (MDA-MB-231)

Cancer

——

553-21-9

232.32

C15H20O2

>98% (HPLC)

DMSO : ≥ 49 mg/mL; 210.92 mM

O1[C@H]2[C@H](C(=C)C1=O)CC/C(=C/CC/C(=C/2)/C)/C

(3aS,6E,10E,11aR)-6,10-dimethyl-3-methylene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2(3H)-one

(-20℃)

With Ice Pack

≥ 2 years