Palmidrol( AM 3112 | Loramine P 256 | Mackpeart DR 14V )

Catalog No. M18772 CAS No. 544-31-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Palmidrol
Note

Research use only, not for human use.
Brief Description

Palmitoylethanolamide(PEA) , an endogenous fatty acid amide, activates PPAR-α selectively in vitro (EC50=3.1±0.4 μM).
Description

Palmitoylethanolamide(PEA) , an endogenous fatty acid amide, activates PPAR-α selectively in vitro (EC50=3.1±0.4 μM).
In Vitro

Palmitoylethanolamide (Palmidrol) itself does not stimulate interferon production in mice treated per os or intravenously. But repeated application of this drug per os induces a macrophage activation, reflected by enhanced interferon production in vitro. When the interferon stimulation is delayed until 4 to 10 days after the first dose of Palmitoylethanolamide, interferon response to ds-RNA is slightly increased. After this phase of enhanced activity a decreased production of interferon is observed. Palmitoylethanolamide is not significantly effective in protecting mice from lethal dose of EMC virus. Application of this drug has an inhibitory effect on the toxicity of ds-RNA. A possible explanation of the mechanism by which Palmitoylethanolamide decreased the toxicity of virus in the organism is discussed.
In Vivo

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Synonyms

AM 3112 | Loramine P 256 | Mackpeart DR 14V
Pathway

GPCR/G Protein
Target

Histamine Receptor
Recptor

PPARα
Research Area

Others-Field
Indication

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1. Lo Verme J, et al. Mol Pharmacol. 2005, 67(1):15-9.

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