dencichine( β-ODAP | Dencichine | BRN-2259036 | Ox-Dapro )

Catalog No. M18743 CAS No. 5302-45-4

Dencichine is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggregation and fibrinolytic system.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	103	In Stock
5MG	93	In Stock
10MG	163	In Stock
25MG	350	In Stock
50MG	509	In Stock
100MG	733	In Stock
200MG	1004	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

dencichine
Note

Research use only, not for human use.
Brief Description

Dencichine is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggregation and fibrinolytic system.
Description

Dencichin, also known as β-ODAP, has been shown to alleviate metabolism disorder, improve renal function, relieve pathological alterations in the glomerulus of diabetic neuropathy in rats, decrease extracellular matrix deposition and increase the ratio of matrix metalloproteinase (MMP)-9 to tissue inhibitor of metalloproteinase (TIMP)-1 both in vivo and in vitro.
In Vitro

Dencichin (β-ODAP, 10 μM, 50 μM, 100 μM and 200 μM) increases HRE expression by 1.3±0.09, 2.5±0.07, 4.2±0.15 and 1.3±0.07 fold respectively compared to control. Dencichin has intermolecular interactions with PHD-2. Dencichin (10 μM, 100 μM, 1 mM) significantly inhibits cell proliferation and extracellular matrix (ECM) proteins accumulation of HBZY-1 cells, and reduces the secretion of collagen I (Col I), collagen IV (Col IV), and fibronectin (FN).
In Vivo

Dencichin improves metabolism disorder in diabetic nephropathy (DN) secondary to type II diabetes mellitus (DM) model. Dencichin (80, 160 mg/kg/day, p.o.) significantly prevents the up-regulation of TCH, TG, LDL, and HbAlc and the down-regulation of HDL in DN rats induced by STZ injection. Dencichin also attenuates renal injury induced in the DN secondary to type II DM model. Dencichin alleviates pancreas damage in the STZ-induced DN model. Dencichin regulates protein expression in the TGF-β/Smad signalling pathway in STZ-induced DN models.
Synonyms

β-ODAP | Dencichine | BRN-2259036 | Ox-Dapro
Pathway

MAPK/ERK Signaling
Target

p38 MAPK
Recptor

Others
Research Area

Others-Field
Indication

——

Chemical Information

CAS Number

5302-45-4
Formula Weight

176.13
Molecular Formula

C5H8N2O5
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : 5 mg/mL (28.39 mM)
SMILES

C([C@@H](C(=O)O)N)NC(=O)C(=O)O
Chemical Name

Oxamic acid, (2-amino-2-carboxyethyl)-, L-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Xie G X, et al. Journal of Pharmaceutical & Biomedical Analysis, 2007, 43(3):920-925.

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