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Nobiletin
CAS No. 478-01-3
Nobiletin( Nobiletin | Hexamethoxyflavone | NOB )
Catalog No. M18598 CAS No. 478-01-3
Nobiletin is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 51 | In Stock |
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| 5MG | 49 | In Stock |
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| 10MG | 77 | In Stock |
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| 25MG | 120 | In Stock |
|
| 50MG | 159 | In Stock |
|
| 100MG | 259 | In Stock |
|
| 200MG | 384 | In Stock |
|
| 500MG | 640 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNobiletin
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NoteResearch use only, not for human use.
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Brief DescriptionNobiletin is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities.
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DescriptionNobiletin has anti-inflammatory and anti-tumor invasion, proliferation, and metastasis activity in vitro and in animal studies. Nobiletin was also found to potentially inhibit cartilage degradation.
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In VitroWestern Blot Analysis Cell Line: U2OS and HOS cells Concentration:0 μM, 25 μM, 50 μM, 75 μM, 100 μM Incubation Time:24 hours Result:Progressively reduced protein expressions of MMP-2 and MMP-9. Considerably reduced the phosphorylation of p-IKKα/β and p-IκBα, and protein expression of NF-κB in the cell nuclear fraction with the concomitant increase of the NF-κB expression in the cytosolic fraction. Down-regulated the p-CREB and the SP-1 expressions in the nuclear fraction in U2OS and HOS cells.RT-PCR Cell Line: U2OS and HOS cells Concentration:0 μM, 25 μM, 50 μM, 75 μM, 100 μM Incubation Time:24 hours Result:Significantly reduced mRNA expressions of MMP-2 and MMP-9 dose-dependently in U2OS and HOS cells.
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In VivoAnimal Model:20- to 22-month-old male C57BL/6 mice Dosage:0.1% of regular diet Administration:Oral administration; daily; for 20 weeks Result:Fully restored glucose tolerance in aged mice, and increased basal body temperature and cold tolerance in aged mice. Led to a twofold increase in distance run/day on voluntary wheels compared with aged regular diet-fed mice during the active phase.
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SynonymsNobiletin | Hexamethoxyflavone | NOB
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PathwayOthers
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TargetOther Targets
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RecptorMMP
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number478-01-3
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Formula Weight402.4
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Molecular FormulaC21H22O8
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 31 mg/mL; 77.04 mM
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SMILESCOc1c(cc(cc1)c1cc(=O)c2c(o1)c(c(c(c2OC)OC)OC)OC)OC
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Chemical Name2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Murakami A, et al. Y Res, 2000, 60(18), 5059-5066.
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