Zigu-glucoside I

Research use only, not for human use.

Ziyuglycoside I has anti-inflammatory activity, could be used as an active ingredient for cosmetics.

Ziyuglycoside I has anti-inflammatory activity, could be used as an active ingredient for cosmetics.

Ziyuglycoside I (5-160 μM; 24 hours) reveals a marked anti-proliferation activity with an IC50 value of 13.96 μM in MDA-MB-231 cells.Ziyuglycoside I (5-20 μM; 24 hours) induces MDA-MB-231 cell apoptosis by increasing the percentage of apoptotic cells from 2.43% to 44.76% at 20 μM.Ziyuglycoside I (5-20 μM; 24 hours) induces the cleavage of caspas-8, caspase-9, and caspase-3, up-regulates the pro-apoptotic protein Bax, and down-regulates anti-apoptotic protein Bal-2, dose-dependently reduces the level of mito-cyto c expression. Cell Viability Assay Cell Line:MDA-MB-231 cells Concentration:5 μM, 10 μM, 20 μM, 40 μM, 80 μM, and 160 μM Incubation Time:24 hours Result:Showed cytotoxicity on MDA-MB-231 cells.Cell Cycle Analysis Cell Line:MDA-MB-231 cells Concentration:5 μM, 10 μM, and 20 μM Incubation Time:24 hours Result:Induced G2/M phase arrest and apoptosis on MDA-MB-231 CellsWestern Blot Analysis Cell Line:MDA-MB-231 cells Concentration:5 μM, 10 μM, and 20 μM Incubation Time:24 hours Result:Induced apoptosis in MDA-MB-231 Cells through Intrinsic and Extrinsic Pathways.

——

——

Others

Other Targets

Others

——

——

35286-58-9

766.97

C41H66O13

>98% (HPLC)

In Vitro:?Methanol : 125 mg/mL (162.98 )

C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]3[C@@]4(CC[C@@H](C3(C)C)O[C@H]3[C@@H]([C@H]([C@H](CO3)O)O)O)C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O

——

(-20℃)

With Ice Pack

≥ 2 years