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L-685,458

CAS No. 292632-98-5

L-685,458( L685458 | L-685458 | L 685458 )

Catalog No. M18379 CAS No. 292632-98-5

L-685, 458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 524 In Stock
5MG 353 In Stock
10MG 549 In Stock
25MG 886 In Stock
50MG 1181 In Stock
100MG 1572 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    L-685,458
  • Note
    Research use only, not for human use.
  • Brief Description
    L-685, 458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
  • Description
    L685458 is a potent and selective γ -secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. L685458 also exhibits equal potency for inhibition of A β 40 and A β 42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro.
  • In Vitro
    ——
  • In Vivo
    Animal Model:NOD-SCID Mouse Hepatoma Model Dosage:5 mg/kg Administration:Percutaneous administration; 5 mg/kg; 2 weeks Result:Exhibited anti-tumor activities in vivo.
  • Synonyms
    L685458 | L-685458 | L 685458
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    γ secretase
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    292632-98-5
  • Formula Weight
    672.85
  • Molecular Formula
    C39H52N4O6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 31 mg/mL; 46.07 mM
  • SMILES
    CC(C)C[C@H](NC(=O)[C@@H](C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
  • Chemical Name
    tert-butyl ((2S,3R,5R)-6-(((S)-1-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl)carbamate.

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Shearman M S, Beher D, Clarke E E, et al. L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid β-protein precursor γ-secretase activity[J]. Biochemistry, 2000, 39(30): 8698-8704.
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