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Bisdemethoxycurcumin

CAS No. 24939-16-0

Bisdemethoxycurcumin( Curcumin III, Bisdemethoxycurcumin )

Catalog No. M18307 CAS No. 24939-16-0

Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 33 In Stock
5MG 29 In Stock
10MG 46 In Stock
25MG 72 In Stock
50MG 100 In Stock
100MG 151 In Stock
200MG Get Quote In Stock
500MG 369 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Bisdemethoxycurcumin
  • Note
    Research use only, not for human use.
  • Brief Description
    Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin.
  • Description
    Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media, BDMC suppresses proliferation of cancer cells. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expression.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Curcumin III, Bisdemethoxycurcumin
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    p300|Wnt/β-catenin
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    24939-16-0
  • Formula Weight
    308.33
  • Molecular Formula
    C19H16O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 66.67 mg/mL (216.23 mM)
  • SMILES
    Oc2ccc(/C=C/C(=O)CC(=O)/C=C/c1ccc(O)cc1)cc2
  • Chemical Name
    (1E,6E)-1,7-Bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Fiala, M., Liu, P.T., Espinosa-Jeffrey, A., et al. Proceedings of the National Academy of Sciences of the United States of America 104(31), 12849-12854 (2007).
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