Lycorine chloride

Research use only, not for human use.

Lycorine chloride is extracted from Lycoris radiata.

Lycorine chloride is extracted from Lycoris radiata.

Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly suppresses the expression of vascular endothelial (VE)-cadherin in a dose-dependent manner and also slightly diminishes the expression of Sema4D in C8161 cells. However, the expression of the other six genes is not affected.Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly reduces VE-cadherin protein levels in C8161 cells in a dose-dependent fashion.RT-PCR Cell Line:C8161 cells Concentration:0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM Incubation Time:48 hours Result:Markedly suppressed the expression of VE-cadherin in a dose-dependent manner and also slightly diminished the expression of Sema4D in C8161 cells.Western Blot Analysis Cell Line:C8161 cells Concentration:0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM Incubation Time:48 hoursResult:Markedly reduced VE-cadherin protein levels in C8161 cells in a dose-dependent fashion.

Lycorine hydrochloride (0-15 μg; subcutaneous injection; for 14 days; BALB/C nude mice) treatment has an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry. Animal Model:6- to 8-week-old BALB/C nude mice Dosage:0 μg, 7.5 μg, 15 μg Administration:Subcutaneous injection; for 14 days Result:Showed an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry.

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Immunology/Inflammation

Antiviral

Others

Cancer

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2188-68-3

323.17

C16H18ClNO4

>98% (HPLC)

DMSO : ≥ 31 mg/mL; 95.75 mM

C1CN2Cc3cc4c(cc3[C@H]3[C@H]2C1=C[C@@H]([C@H]3O)O)OCO4.Cl

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(-20℃)

With Ice Pack

≥ 2 years