Oxytetracycline Hydrochloride

Research use only, not for human use.

Oxytetracycline Hydrochloride is a tetracycline derivative produced by Streptomyces rimosus with antimicrobial activity.

Oxytetracycline Hydrochloride is a tetracycline derivative produced by Streptomyces rimosus with antimicrobial activity. It interferes with the binding of aminoacyl-tRNA to the mRNA-ribosome complex, resulting in preventing peptide elongation and inhibiting protein synthesis.(In Vivo):The 10-day effect of oxytetracycline at therapeutic doses (82.8 mg/kg bw to 1 % bw/day) was species-specific. Oxytetracycline increases the enzymatic activity of CYP3A4 in Ictalurus punctatus, increases the protein expression of CYP3A4 in Oreochromis niloticus, and depletes hepatic CYP3A4 in the latter, and also increases the relative liver weight of Morone chrysops x M. saxatilis . Oxytetracycline is limited to 100 μg/kg in muscle and breast milk, 200 μg/kg in eggs, 300 μg/kg in liver, and 600 μg/kg in kidney.

Oxytetracycline is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. Oxytetracycline is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes.

The effects of administration a therapeutic dose of Oxytetracycline (82.8 mg/kg of bw to 1 % bw/day) for 10 days are species specific. Oxytetracycline increases the relative liver weight in Morone chrysops x M. saxatilis, the enzymatic activity of CYP3A4 in Ictalurus punctatus, protein expression of CYP3A4 in Oreochromis niloticus and depleted the hepatic CYP3A4 in the latter.For Oxytetracycline, the limits are 100 μg/kg in muscle and milk, 200 μg/kg in egg, 300 μg/kg in liver and 600 μg/kg in kidney. Oxytetracycline (OTC) is administered to fish as medicated feed at concentrations ranging from 35 to 75 mg a.i kg-1 biomass day-1 for 7-14 days.

Oxytetracycline HCl | Biosolvomycin | Oxytetracycline.HCl | Dalinmycin | Dalimycin | Oxytetracycline, Sodium Salt

Immunology/Inflammation

Antiviral

Calcium Channel

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2058-46-0

496.9

C22H25ClN2O9

>98% (HPLC)

In Vitro:?DMSO : 500 mg/mL (1006.26 mM)

Cl.CN(C)C1C2C(O)C3C(=C(O)c4c(O)cccc4C3(C)O)C(=O)C2(O)C(O)=C(C(N)=O)C1=O

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(-20℃)

With Ice Pack

≥ 2 years