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Gentiopicrin
CAS No. 20831-76-9
Gentiopicrin( O673 | O-673 | O 673 | SC-46058 )
Catalog No. M18227 CAS No. 20831-76-9
Gentiopicroside, a naturally occurring iridoid glycoside, extracted from Gentiana manshurica Kitag, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22.8 μM for CYP2A6.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 33 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 53 | In Stock |
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| 25MG | 101 | In Stock |
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| 50MG | 160 | In Stock |
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| 100MG | 259 | In Stock |
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| 200MG | 388 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameGentiopicrin
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NoteResearch use only, not for human use.
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Brief DescriptionGentiopicroside, a naturally occurring iridoid glycoside, extracted from Gentiana manshurica Kitag, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22.8 μM for CYP2A6.
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DescriptionGentiopicrin is found in gentiana and cephalaria. It displays many biological properties, including suppressing expression of NMDA receptors in the anterior cingulate cortex, inhibiting morphine conditioned place preference, and preventing arachidonic acid and PMA-induced superoxide generation.
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In VitroGentiopicroside inhibits P450 activity, with an IC50 and a Ki of 61 μM and 8.12 μM for CYP2A6, also slightly inhibits CYP2E1 activity with an IC50 of 1.6 mM, but shows no inhibition on CYP1A2 and CYP3A4. Gentiopicroside (12.5, 25 and 50?μM) inhibits RANKL-induced osteoclast formation from mouse bone marrow macrophages (BMMs) in a dose-dependent manner, blocks the expression of osteoclast-related proteins, prevents receptor activator of nuclear factor-κB ligand (RANKL)-triggered JNK and NF-κB activation. Gentiopicroside (50?μM) also inhibits RANKL-induced bone resorption.
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In VivoGentiopicroside (20, 40, and 80 mg/kg, p.o.) significantly reduces gastric ulcerindex in mice. Gentiopicroside (20, 40, and 80 mg/kg) also ovbiously decreases the levels of HSP-70, TNF-α, IL-6, MDA and increases ncreased GSH level and SOD activity. In addition, Gentiopicroside normalizes EGF and VEGF level in mice.
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SynonymsO673 | O-673 | O 673 | SC-46058
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number20831-76-9
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Formula Weight356.33
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Molecular FormulaC16H20O9
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 150 mg/mL; 420.97 mM
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SMILESC=C[C@H]1[C@@H](OC=C2C1=CCOC2=O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O
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Chemical Name(5R,6S)-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5-vinyl-5,6-dihydro-1H,3H-pyrano[3,4-c]pyran-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhang K, et al. Int J Nanomedicine. 2013;8:3227-39.
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