Methiothepin maleate

CAS No. 19728-88-2

Methiothepin maleate( Methiothepin Maleate | Metitepine | HCVIN281816 )

Catalog No. M18192 CAS No. 19728-88-2

Methiothepin is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
50MG 56 Get Quote
100MG 102 Get Quote
200MG Get Quote Get Quote
500MG 381 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Methiothepin maleate
  • Note
    Research use only, not for human use.
  • Brief Description
    Methiothepin is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.
  • Description
    Methiothepin Maleate is an inhibitor of HCV infection and cell-to-cell transmission that acts by targeting the HCV E2 glycoprotein.
  • In Vitro
    Methiothepin maleate is a 5-HT receptor antagonist, with pKds of 7.10, 7.28, 7.56, and 6.99 for 5-HT1A, 5HT1B, 5HT1C, 5HT1D. Methiothepin mesylate also shows pKds of 7.0, 7.8, 8.74, and 8.99 for 5-HT5A, 5-HT5B, 5-HT6, and 5-HT7, respectively. Methiothepin exhibits high affinity at 5-HT2A, 5HT2B, and 5HT2C with pKis of 8.50, 8.68, and 8.35, respectively.
  • In Vivo
    ——
  • Synonyms
    Methiothepin Maleate | Metitepine | HCVIN281816
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    5-HT1|5-HT6|5-HT7
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    19728-88-2
  • Formula Weight
    472.62
  • Molecular Formula
    C24H28N2O4S2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)SC.C(=CC(=O)O)C(=O)O
  • Chemical Name
    1-Methyl-4-(3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)piperazine Maleate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Knight J A, etal. Molecular Pharmacology, 2009, 75(2):374-380.
molnova catalog
related products
  • HA Peptide

    Influenza Hemagglutinin (HA) Peptide is a tag peptide derived from an epitope of the influenza hemagglutinin protein.HA Peptide is a highly immunoreactive tag generally used for the separation of tagged proteins from cell culture supernatants and cell lysate under neutral pH conditions and thus are handy tools for coimmunoprecipitation but are also easily detected via western blot.

  • Ranatensin

    Ranatensin is a undecapeptide and a Bombesin Receptor angonist, can be isolated from amphibian skin, such as the frog, Rana pipiens. Ranatensin could maintain the dynamic balance of animal blood pressure, without cross-tachyphylaxis with Angiotensin amide, Bradykinin , or Norepinephrine .

  • Hepatitus B Virus Pr...

    Hepatitis b virus pre-s region (120-145) is a preS2 peptide that inhibits the binding of single-chain Fv fragment (scFv) or IgG to r-HBsAg.