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NCT-503
CAS No. 1916571-90-8
NCT-503( NCT-503 | NCT 503 | NCT503 )
Catalog No. M18172 CAS No. 1916571-90-8
NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 60 | In Stock |
|
| 2MG | 33 | In Stock |
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| 5MG | 54 | In Stock |
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| 10MG | 87 | In Stock |
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| 25MG | 187 | In Stock |
|
| 50MG | 332 | In Stock |
|
| 100MG | 492 | In Stock |
|
| 200MG | 690 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNCT-503
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NoteResearch use only, not for human use.
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Brief DescriptionNCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells.
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DescriptionNCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 value of 2.5 μM.
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In Vitro——
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In Vivo——
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SynonymsNCT-503 | NCT 503 | NCT503
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PathwayOthers
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TargetOther Targets
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RecptorPHGDH(Cell-free)| FLT3| AXL
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Research Area——
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Indication——
Chemical Information
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CAS Number1916571-90-8
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Formula Weight408.49
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Molecular FormulaC20H23F3N4S
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Purity>98% (HPLC)
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SolubilityDMSO : 50 mg/mL 122.41 mM;
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SMILESCc1cc(nc(c1)NC(=S)N1CCN(CC1)Cc1ccc(cc1)C(F)(F)F)C
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Chemical NameN-(4,6-dimethylpyridin-2-yl)-4-(4-(trifluoromethyl)benzyl)piperazine-1-carbothioamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Pacold ME, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jun;12(6):452-8.
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