Phosphoramidon Disodium Salt( Phosphoramidon disodium )

Catalog No. M18103 CAS No. 164204-38-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

Phosphoramidon Disodium Salt
Note

Research use only, not for human use.
Brief Description

Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool.
Description

Phosphoramidon disodium is a neutral endopeptidase (neprilysin) inhibitor. It blocks degradation of amyloid β peptides and endothelin converting enzyme (ECE).
In Vitro

Phosphoramidon (1-500 μM; 30 min) inhibits ET-converting enzyme (ECE) activity in a dose-dependent manner in solubilized rabbit lung membranes.
In Vivo

Phosphoramidon (0.25 mg/kg per min; i.v.) suppresses the hypertensive effect of big endothelin-1 in rats. Phosphoramidon (1-30 mg/kg; i.v.; once) blocks the pressor activity of porcine big endothelin-1-(1-39) in rats. Animal Model:Male Sprague-Dawley ratsDosage:0.25 mg/kg per min Administration:Intravenous injection Result:Markedly suppressed the hypertensive effect of big endothelin-1.
Synonyms

Phosphoramidon disodium
Pathway

Others
Target

Other Targets
Recptor

metalloendopeptidase
Research Area

Others-Field
Indication

——

CAS Number

164204-38-0
Formula Weight

588.48
Molecular Formula

C23H34N3Na2O10P
Purity

>98% (HPLC)
Solubility

H2O : ≥ 140 mg/mL; 238.31 mM
SMILES

[Na][Na].CC(C)C[C@H](NP(O)(=O)O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O)C(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(O)=O
Chemical Name

sodium (oxido(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)phosphoryl)-L-leucyl-L-tryptophanate

1. Komiyama T, et al. Biochem Biophys Res Commun. 1975, 65(1), 352-357.

Calculator

molnova catalog