Picolinamide

Research use only, not for human use.

Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.

Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.

Picolinamide (10 μM-1 mM) inhibits Poly(ADP-ribose) synthetase activity.Picolinamide (2 mM) protects against streptozotocin-induced depression of proinsulin synthesis in isolated pancreatic islets of rats.

Picolinamide (4 mmol/kg, i.p., rats) inhibits Na+/phosphate cotransport by isolated renal brush border membrane vesicles.Picolinamide (250 mg/kg, i.p., rats) enhances the tumorigenic effect of Streptozotocin and Alloxan on islet B-cells. Animal Model:Rats Dosage:4 mmol/kg Administration:Intraperitoneal injection (i.p.)Result:Increased renal cortical NAD content (1.5 fold).

——

Others

Other Targets

PARP

Cancer

——

1452-77-3

122.12

C6H6N2O

>98% (HPLC)

In Vitro:?H2O : 100 mg/mL (818.87 mM)

C1=CC=NC(=C1)C(=O)N

——

(-20℃)

With Ice Pack

≥ 2 years