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ML297
CAS No. 1443246-62-5
ML297( ML297 | ML 297 | ML-297 )
Catalog No. M18019 CAS No. 1443246-62-5
ML297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 44 | In Stock |
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| 5MG | 41 | In Stock |
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| 10MG | 69 | In Stock |
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| 25MG | 130 | In Stock |
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| 50MG | 191 | In Stock |
|
| 100MG | 297 | In Stock |
|
| 200MG | 427 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameML297
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NoteResearch use only, not for human use.
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Brief DescriptionML297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively).
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DescriptionML297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively). ML297 exhibits no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels, and has minimal effect on a panel of other ion channels, receptors and transporters.
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In VitroML 297 is completely inactive for GIRK2/3.ML297 shows concentration-dependent efficacy in expressing GIRK1/2 cells and with an EC50 of 162 nM. ML297 shows a complete inability to modulate the activity of HEK-293 cells expressing GIRK2 alone and GIRKGIRK2/3.
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In VivoML297 (60 mg/kg; i.p.) shows a highly significant ability to both prevent convulsions and prevent fatality of the PTZ treatment. Animal Model:8-10 months old C57/BL6 male mice (approximately 30 g)Dosage:60 mg/kg Administration:Intraperitoneal injectionResult:Most of the animals neither convulsions nor death.
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SynonymsML297 | ML 297 | ML-297
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PathwayOthers
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TargetOther Targets
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RecptorGIRK1/2
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Research Area——
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Indication——
Chemical Information
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CAS Number1443246-62-5
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Formula Weight328.11
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Molecular FormulaC17H14F2N4O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (761.45 mM)
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SMILESFc1ccc(cc1F)NC(=O)Nc3cc(C)nn3c2ccccc2
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Chemical Name1-(3,4-difluorophenyl)-3-(5-methyl-2-phenylpyrazol-3-yl)urea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Nimitvilai S, Lopez MF, Mulholland PJ, Woodward JJ. Neuropsychopharmacology. 2017 Aug;42(9):1800-1812.
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