Arctigenin

Research use only, not for human use.

Arctigenin is a lignan found in certain plants of the Asteraceae;  it has shown antiviral and anticancer effects in glass.

Arctigenin is a lignan found in certain plants of the Asteraceae;  it has shown antiviral and anticancer effects in glass; it is the aglycone of arctiin.(In Vitro):Arctigenin (0.01-1 μg/mL; 0.5-24 h) shows preferential cytotoxicity against the PANC-1 cell line under nutrient-deprived conditions in a concentration- and time-dependent manner.Arctigenin (0.01-1 μg/mL; 0.5-24 h) inhibits the survival of various cancer cell lines (ASPC-1, BXPC-3, Alexander, and PSN-1 cells) under nutrient-deprived conditions.Arctigenin (0.1-1 μg/mL; 24 h) completely inhibits Akt phosphorylation stimulated by glucose deprivation in PANC-1 cells.Arctigenin (5-25 μM) shows potent in vitro antiviral activities (IC50=2.9 μM) against influenza A virus.(In Vivo):Arctigenin (250 μg/mL; 0.2 mL; i.p. 6 times a week for 9 weeks) suppress the PANC-1 tumor growth in nude mice.Arctigenin (10 mg/kg; i.p. daily for 30 days) relieves experimental autoimmune encephalomyelitis (EAE) symptoms of mice.

Arctigenin (0.01-1 μg/mL; 0.5-24 h) shows preferential cytotoxicity against the PANC-1 cell line under nutrient-deprived conditions in a concentration- and time-dependent manner.?Arctigenin (0.01-1 μg/mL; 0.5-24 h) inhibits the survival of various cancer cell lines (ASPC-1, BXPC-3, Alexander, and PSN-1 cells) under nutrient-deprived conditions.?Arctigenin (0.1-1 μg/mL; 24 h) completely inhibits Akt phosphorylation stimulated by glucose deprivation in PANC-1 cells.?Arctigenin (5-25 μM) shows potent in vitro antiviral activities (IC50=2.9 μM) against influenza A virus.

Arctigenin (250 μg/mL; 0.2 mL; i.p. 6 times a week for 9 weeks) suppress the PANC-1 tumor growth in nude mice.Arctigenin (10 mg/kg; i.p. daily for 30 days) relieves experimental autoimmune encephalomyelitis (EAE) symptoms of mice. Animal Model:Female SPF/VAF BALB/cAn Ncrj-nu/nu mice were injected with PANC-1 cells Dosage:250 μg/mL, 0.2 mL Administration:I.p. 6 times a week for 9 weeks Result:Reduced the tumor weight and volume.

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Others

Other Targets

Others

Cancer

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7770-78-7

372.41

C21H24O6

>98% (HPLC)

DMSO: 10 mM

O=C1OC[C@H](CC2=CC=C(OC)C(OC)=C2)[C@H]1CC3=CC=C(O)C(OC)=C3

(3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3- [(4-hydroxy-3-methoxyphenyl)methyl]-2-tetrahydrofuranone

(-20℃)

With Ice Pack

≥ 2 years