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Cerdulatinib hydrochloride
CAS No. 1369761-01-2
Cerdulatinib hydrochloride( —— )
Catalog No. M17977 CAS No. 1369761-01-2
Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 29 | In Stock |
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| 5MG | 49 | In Stock |
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| 10MG | 67 | In Stock |
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| 25MG | 113 | In Stock |
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| 50MG | 166 | In Stock |
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| 100MG | 254 | In Stock |
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| 200MG | 361 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCerdulatinib hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionCerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively.
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DescriptionCerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Also inhibits 19 other tested kinases with IC50 less than 200 nM.
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In VitroCell Viability Assay Cell Line:SU-DHL4; SU-DHL6; Ramosand and Daudi cells Concentration:0, 1, 3 μM Incubation Time:48 hours Result:Inhibits cells viability with the IC50s of 0.73-1.39 μM.Apoptosis Analysis Cell Line:SU-DHL4, SU-DHL6, and Ramos cells Concentration:0, 1.6, 5.0, 15 μM Incubation Time:72 hours Result:Induced SU-DHL4, SU-DHL6, and Ramos cells apoptosis.
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In VivoAnimal Model:Female Lewis rats (7-8 weeks old; 159-187 g) are immunizedDosage:0, 0.5, 1.5, 3, 5?mg/kg Administration:Oral gavage twice daily for 2 weeks Result:Modulated inflammation in the rat CIA treatment model.Affected anticollagen antibody formation.Animal Model:Balb/c mice are received BCR stimulation Dosage:0, 1, 5, 15, 20, 30?mg/kg Administration:Oral gavage twice daily for 5 days Result:Suppressed upregulation of splenic B-cell surface CD80/86 and CD69 by＞60%.Inhibited mouse splenomegaly in a dose- and concentration-dependent manner.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptorc-Fms| MST1| ARK5| MLK1| Tyk2
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Research AreaCancer|Inflammation/Immunology
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Indication——
Chemical Information
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CAS Number1369761-01-2
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Formula Weight482
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Molecular FormulaC20H28ClN7O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 20 mg/mL (41.49 mM)
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SMILESCl.CCS(=O)(=O)N1CCN(CC1)C1=CC=C(NC2=NC(NC3CC3)=C(C=N2)C(N)=O)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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