Cart
sales@molnova.com
GNE-617
CAS No. 1362154-70-8
GNE-617( GNE-617 | GNE 617 | GNE617 )
Catalog No. M17972 CAS No. 1362154-70-8
GNE-617, a specific NAMPT inhibitor(IC50=5 nM), shows potency in xenograft models of cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 74 | In Stock |
|
| 2MG | 46 | In Stock |
|
| 5MG | 73 | In Stock |
|
| 10MG | 120 | In Stock |
|
| 25MG | 219 | In Stock |
|
| 50MG | 343 | In Stock |
|
| 100MG | 511 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1107 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameGNE-617
-
NoteResearch use only, not for human use.
-
Brief DescriptionGNE-617, a specific NAMPT inhibitor(IC50=5 nM), shows potency in xenograft models of cancer.
-
DescriptionGNE-617 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with IC50 value of 5nM. Prolonged inhibition of nicotinamide phosphoribosyltransferase (NAMPT) is a strategy for targeting cancer metabolism.
-
In Vitro——
-
In Vivo——
-
SynonymsGNE-617 | GNE 617 | GNE617
-
PathwayMAPK/ERK Signaling
-
TargetJNK
-
RecptorNAMPT
-
Research AreaMetabolic Disease
-
Indication——
Chemical Information
-
CAS Number1362154-70-8
-
Formula Weight427.43
-
Molecular FormulaC21H15F2N3O3S
-
Purity>98% (HPLC)
-
SolubilityDMSO : ≥ 42.85 mg/mL; 100.25 mM
-
SMILESC1=CC(=CC=C1CNC(=O)C2=CN3C=CN=C3C=C2)S(=O)(=O)C4=CC(=CC(=C4)F)F
-
Chemical NameN-(4-((3,5-difluorophenyl)sulfonyl)benzyl)imidazo[1,2-a]pyridine-6-carboxamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Shames DS, et al. Loss of NAPRT1 Expression by Tumor-specific Promoter Methylation Provides a Novel Predictive Biomarker for NAMPT Inhibitors. Clin Cancer Res. 2013 Dec 15;19(24):6912-23.
molnova catalog
related products
-
6-CFDA N-succinimidy...
The succinimidyl ester group is capable of spontaneously and irreversibly binding to free amines. Utilized in flow cytometry experiments for tracking cell division in both mammalian cells and bacteria.
-
JNK Inhibitor VIII
JNK Inhibitor VIII is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2, respectively).
-
BI-78D3
A small molecule JIP1 mimic that functions as substrate competitive inhibitor of JNK with IC50 of 500 nM.
