GNE-617( GNE-617 | GNE 617 | GNE617 )

Catalog No. M17972 CAS No. 1362154-70-8

GNE-617, a specific NAMPT inhibitor(IC50=5 nM), shows potency in xenograft models of cancer.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	74	In Stock
2MG	46	In Stock
5MG	73	In Stock
10MG	120	In Stock
25MG	219	In Stock
50MG	343	In Stock
100MG	511	In Stock
200MG	Get Quote	In Stock
500MG	1107	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

GNE-617
Note

Research use only, not for human use.
Brief Description

GNE-617, a specific NAMPT inhibitor(IC50=5 nM), shows potency in xenograft models of cancer.
Description

GNE-617 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with IC50 value of 5nM. Prolonged inhibition of nicotinamide phosphoribosyltransferase (NAMPT) is a strategy for targeting cancer metabolism.
In Vitro

——
In Vivo

——
Synonyms

GNE-617 | GNE 617 | GNE617
Pathway

MAPK/ERK Signaling
Target

JNK
Recptor

NAMPT
Research Area

Metabolic Disease
Indication

——

Chemical Information

CAS Number

1362154-70-8
Formula Weight

427.43
Molecular Formula

C21H15F2N3O3S
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 42.85 mg/mL; 100.25 mM
SMILES

C1=CC(=CC=C1CNC(=O)C2=CN3C=CN=C3C=C2)S(=O)(=O)C4=CC(=CC(=C4)F)F
Chemical Name

N-(4-((3,5-difluorophenyl)sulfonyl)benzyl)imidazo[1,2-a]pyridine-6-carboxamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Shames DS, et al. Loss of NAPRT1 Expression by Tumor-specific Promoter Methylation Provides a Novel Predictive Biomarker for NAMPT Inhibitors. Clin Cancer Res. 2013 Dec 15;19(24):6912-23.

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