Amikacin hydrate( —— )

Catalog No. M17911 CAS No. 1257517-67-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Amikacin hydrate
Note

Research use only, not for human use.
Brief Description

Amikacin is an aminoglycoside antibiotic used to treat different types of bacterial infections.
Description

Amikacin is an aminoglycoside antibiotic used to treat different types of bacterial infections.
In Vitro

Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused by Nocardia asteroides, Mycobacterium avium-intracellulare, and certain species of "rapid-growing" mycobacteria (that is, M. chelonae and M. fortuitumi).Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD50 value of 453 μM.
In Vivo

Amikacin (320?mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo. Animal Model:Male Fischer 344 rats (40-50-day-old) Dosage:320?mg/kg Administration:Subcutaneous injection; daily; for 10 days Result:Induced hearing loss in rats.
Synonyms

——
Pathway

Endocrinology/Hormones
Target

AChR
Recptor

Others
Research Area

Others-Field
Indication

——

CAS Number

1257517-67-1
Formula Weight

——
Molecular Formula

C22H43N5O13·xH2O
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : 50 mg/mL
SMILES

O.[*].[H][C@]1(O[C@@H]2[C@@H](N)C[C@@H](NC(=O)[C@@H](O)CCN)[C@H](OC3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O
Chemical Name

——

1. Possoz C, et al. Antimicrob Agents Chemother, 2007, 51(1), 252-6.

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