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SKLB1002
CAS No. 1225451-84-2
SKLB1002( SKLB1002 | SKLB 1002 | SKLB1002 )
Catalog No. M17891 CAS No. 1225451-84-2
SKLB1002 is a potent and ATP-competitive VEGFR2 inhibitor with IC50 of 32 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 29 | In Stock |
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| 5MG | 41 | In Stock |
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| 10MG | 54 | In Stock |
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| 25MG | 124 | In Stock |
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| 50MG | 201 | In Stock |
|
| 100MG | 326 | In Stock |
|
| 200MG | 456 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSKLB1002
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NoteResearch use only, not for human use.
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Brief DescriptionSKLB1002 is a potent and ATP-competitive VEGFR2 inhibitor with IC50 of 32 nM.
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DescriptionSKLB1002 is a new potent VEGFR2 inhibitor, which could significantly inhibit HUVEC proliferation, migration, invasion, and tube formation. Western blot analysis was conducted, which indicated that SKLB1002 inhibited VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal-regulated kinase, focal adhesion kinase, and Src. In vivo zebrafish model experiments showed that SKLB1002 remarkably blocked the formation of intersegmental vessels in zebrafish embryos. SKLB1002 inhibits angiogenesis and may be a potential drug candidate in anticancer therapy.
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In Vitro——
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In Vivo——
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SynonymsSKLB1002 | SKLB 1002 | SKLB1002
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PathwayOthers
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TargetOther Targets
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RecptorVEGFR2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1225451-84-2
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Formula Weight320.39
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Molecular FormulaC13H12N4O2S2
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Purity>98% (HPLC)
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SolubilityDMSO : 5.625 mg/mL 17.56 mM;
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SMILESCOc1c(OC)cc2c(Sc3nnc(C)s3)ncnc2c1
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Chemical Name2-((6,7-dimethoxyquinazolin-4-yl)thio)-5-methyl-1,3,4-thiadiazole
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Epimagnolin A
Epimagnolin A is a lignan obtained from the flower buds of Magnolia fargesii, which is traditionally used in Asian medicine for treating headache and nasal congestion.?A herbal compound fargesin obtained from M. fargesii, has exerted anti-inflammatory effects in human monocytic THP-1 cells in the previous study.?it was demonstrated that epimagnolin A reduced phorbol-12-myristate-13-acetate (PMA)-induced IL-6 promoter activity and IL-6 production in human monocytic THP-1 cells.?
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EC5026
EC5026 has the potential to relieve pain by stabilizing natural analgesic and anti-inflammatory mediators.?EC5026 (BPN-19186) is a first-in-class, small molecule that potently inhibits soluble Epoxide Hydrolase (sEH), a key regulatory enzyme involved in the metabolism of membrane fatty acids.?Inhibition of sEH treats pain by stabilizing natural analgesic and anti-inflammatory mediators.
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Polygalasaponin XXXI
Onjisaponin F(Polygalasaponin XXXI) acts non-competitively against cyclic AMP phosphodiesterase, like papaverine; it also exhibits a prolongation effect on hexobarbital sleeping time in mice.
