SKLB1002( SKLB1002 | SKLB 1002 | SKLB1002 )

Catalog No. M17891 CAS No. 1225451-84-2

COA

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Product Name

SKLB1002
Note

Research use only, not for human use.
Brief Description

SKLB1002 is a potent and ATP-competitive VEGFR2 inhibitor with IC50 of 32 nM.
Description

SKLB1002 is a new potent VEGFR2 inhibitor, which could significantly inhibit HUVEC proliferation, migration, invasion, and tube formation. Western blot analysis was conducted, which indicated that SKLB1002 inhibited VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal-regulated kinase, focal adhesion kinase, and Src. In vivo zebrafish model experiments showed that SKLB1002 remarkably blocked the formation of intersegmental vessels in zebrafish embryos. SKLB1002 inhibits angiogenesis and may be a potential drug candidate in anticancer therapy.
In Vitro

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In Vivo

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Synonyms

SKLB1002 | SKLB 1002 | SKLB1002
Pathway

Others
Target

Other Targets
Recptor

VEGFR2
Research Area

Cancer
Indication

——

CAS Number

1225451-84-2
Formula Weight

320.39
Molecular Formula

C13H12N4O2S2
Purity

>98% (HPLC)
Solubility

DMSO : 5.625 mg/mL 17.56 mM;
SMILES

COc1c(OC)cc2c(Sc3nnc(C)s3)ncnc2c1
Chemical Name

2-((6,7-dimethoxyquinazolin-4-yl)thio)-5-methyl-1,3,4-thiadiazole

1. Zhang S, et al. Clin Y Res. 2011, 17(13), 4439-4450.

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