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Amifostine trihydrate
CAS No. 112901-68-5
Amifostine trihydrate( —— )
Catalog No. M17831 CAS No. 112901-68-5
Amifostine is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 29 | In Stock |
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| 10MG | 48 | In Stock |
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| 25MG | 85 | In Stock |
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| 50MG | 117 | In Stock |
|
| 100MG | 164 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 389 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAmifostine trihydrate
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NoteResearch use only, not for human use.
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Brief DescriptionAmifostine is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
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DescriptionAmifostine is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
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In VitroAmifostine (0.78125-100?μM, 24 h)trihydrate reduces tert-Butyl hydroperoxide (TBHP)-induced cell damage in a dose-dependent manner and significantly reduces H9c2 cells apoptosis at a concentration of 100 μM.
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In VivoAmifostine (i.v., 400 mg/kg, 4 h) trihydrate has a protective effect against myocardial I/R injury in male C57BL/6 mice. Animal Model:Male C57BL/6 mice with myocardial I/R injury Dosage:400 mg/kg Administration: Intravenous injection; 4 hours Result:Attenuated cardiomyocyte apoptosis and reduced the production of I/R-induced ROS.Significantly reduced the expression of cleaved caspase 3 and Bax whileenhanced the expression of SOD1, SOD2 and Bcl2.Significantly increased SOD activity and reduced MDA levels.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number112901-68-5
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Formula Weight268.27
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Molecular FormulaC5H15N2O3PS·3H2O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 125 mg/mL (465.95 mM)
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SMILESO.O.O.NCCCNCCSP(O)(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Tas S, Ozkul F, Arik MK, Kiraz A, Vural A.Acta Cir Bras. 2016 Mar;31(3):156-60.
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