Ascomycin( FK-520 | FR900520 | L-683590 | Changchuanmycin )

Catalog No. M17780 CAS No. 104987-12-4

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Product Name

Ascomycin
Note

Research use only, not for human use.
Brief Description

Ascomycin(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.
Description

Ascomycin, also known as KF-520, FR900520, L 683590, produced by the fermentation of S. hygroscopicus subsp. ascomyceticus, is an ethyl analog of tacrolimus (FK-506) with potent immunosuppressant properties.
In Vitro

——
In Vivo

——
Synonyms

FK-520 | FR900520 | L-683590 | Changchuanmycin
Pathway

Others
Target

Other Targets
Recptor

calcineurin phosphatase
Research Area

Infection
Indication

——

CAS Number

104987-12-4
Formula Weight

792.01
Molecular Formula

C43H69NO12
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 39 mg/mL; 49.24 mM
SMILES

O1[C@@]2(O)C(=O)C(=O)N3[C@H](C(=O)O[C@@H]([C@@H]([C@@H](O)CC(=O)[C@@H](/C=C(/C[C@@H](C[C@H](OC)[C@@H]1[C@@H](OC)C[C@H]2C)C)\C)CC)C)/C(=C/[C@H]1C[C@@H](OC)[C@H](O)CC1)/C)CCCC3
Chemical Name

(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone

1. Hatanaka H, et al. J Antibiot (Tokyo). 1988, 41(11), 1592-1601.

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