FERULIC ACID METHYL ESTER

Research use only, not for human use.

Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis).

Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis). This naturally-occurring phenolic has antioxidant activities that provide protection against inflammation and cancer. Ferulic acid methyl ester is a lipophilic derivative of ferulic acid, demonstrating increased ability to cross cell membranes.(In Vitro):Ferulic acid methyl ester (25 μg/mL) has no cytotoxic effects on BMDMs after treatment for 6 h, 18 h, 48 h.Ferulic acid methyl ester (Methyl ferulate; 5, 10, 25 μg/mL) suppresses TNFα, IL6, IFNγ but not IL10, inhibits NO generation at 10 and 25 μg/mL, in primary bone marrow derived-macrophages (BMDMs).Ferulic acid methyl ester (25 μg/mL) inhibits COX-2 expression, blocks p-p38 and p-JNK.

Ferulic acid methyl ester (25 μg/mL) has no cytotoxic effects on BMDMs after treatment for 6 h, 18 h, 48 h.Ferulic acid methyl ester (Methyl ferulate; 5, 10, 25 μg/mL) suppresses TNFα, IL6, IFNγ but not IL10, inhibits NO generation at 10 and 25 μg/mL, in primary bone marrow derived-macrophages (BMDMs).Ferulic acid methyl ester (25 μg/mL) inhibits COX-2 expression, blocks p-p38 and p-JNK. Cell Viability Assay Cell Line:Primary bone marrow derived-macrophages (BMDMs)C oncentration:25 μg/mL Incubation Time:6 h, 18 h, 48 hResult:Showed no cytotoxic effects on BMDMs.Western Blot Analysis Cell Line:RAW 246.7 cells Concentration:10 μg/mL and 25 μg/mL Incubation Time:For 1 h before stimulation with LPS Result:Significantly suppressed COX-2 expression at 25 μg/mL.

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Methyl ferulate

Others

Other Targets

Others

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2309-07-1

208.21

C11H12O4

>98% (HPLC)

DMSO : ≥ 100 mg/mL480.28 mM; H2O : 2 mg/mL9.61 mM;

Oc1ccc(cc1OC)/C=C/C(=O)OC

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(-20℃)

With Ice Pack

≥ 2 years