BMS-303141( BMS303141 | BMS-303141 | BMS 303141 )

Catalog No. M17681 CAS No. 943962-47-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

BMS-303141
Note

Research use only, not for human use.
Brief Description

BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).
Description

BMS303141 is a potent inhibitor of ATP citrate lyase (ACL). BMS-303141 inhibits lipid synthesis in HepG2 cells with an IC50 of 8 μM, and lowers plasma triglycerides in a murine hyperlipdemia model.
In Vitro

In HepG2 cells, BMS-303141 shows inhibition of total lipid syntheses with an IC50 of 8 μM. BMS-303141 shows no cytotoxicity up to 50 lM under a cell based Alamar Blue cytotoxicity assay, indicating the observed inhibition of lipid synthesis is not a result of compound-induced cytotoxicity.
In Vivo

Chronic oral dosing of BMS-303141 in high-fat fed mice lowers approximate 20-30% plasma cholesterol and triglycerides, as well as 30-50% fasting plasma glucose. Chronic treatment with BMS-303141 shows a gradual inhibition of weight gain along with a reduction in adiposity without apparent changes in food intake. BMS-303141 shows an oral bioavailability of 55% but a relatively short half-life of 2.1 h.
Synonyms

BMS303141 | BMS-303141 | BMS 303141
Pathway

Endocrinology/Hormones
Target

AChR
Recptor

ACL
Research Area

Metabolic Disease
Indication

——

CAS Number

943962-47-8
Formula Weight

424.3
Molecular Formula

C19H15Cl2NO4S
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 47 mg/mL; 110.77 mM
SMILES

c1c(cccc1)c1cc(c(cc1)OC)NS(=O)(=O)c1c(O)c(cc(c1)Cl)Cl
Chemical Name

3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1′-biphenyl]-3-yl)-benzenesulfonamide

1. Li JJ, et al. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3208-11.

Calculator

molnova catalog