Irbinitinib( ARRY380 | ARRY 380 | ONT-380. Irbinitinib | Tucatinib )

Catalog No. M17675 CAS No. 937263-43-9

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HNMR

HPLC

MSDS

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Product Name

Irbinitinib
Note

Research use only, not for human use.
Brief Description

Irbinitinib(ARRY-380; ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).
Description

Tucatinib, also known as Irbinitinib, ARRY-380 and ONT-380, is a n orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.
In Vitro

——
In Vivo

Animal Model:Female nude mice.Dosage:200 mg/kg/d.Administration:PO, daily. Result:Exhibited anti-tumor activity and benefited survival.
Synonyms

ARRY380 | ARRY 380 | ONT-380. Irbinitinib | Tucatinib
Pathway

Neuroscience
Target

GluR
Recptor

EGFR| HER2/ErbB2| p95 HER2
Research Area

Cancer
Indication

——

CAS Number

937263-43-9
Formula Weight

480.52
Molecular Formula

C26H24N8O2
Purity

>98% (HPLC)
Solubility

DMSO : 50 mg/mL. 104.05 mM;
SMILES

Cc1c(ccc(c1)Nc1ncnc2c1cc(cc2)NC1=NC(CO1)(C)C)Oc1cc2ncnn2cc1
Chemical Name

N6-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)-N4-(3-methyl-4-((1,2,4)triazolo(1,5-a)pyridin-7-yloxy)phenyl)quinazoline-4,6-diamine

1. P Lee, et al. Cancer Research(Poster Session Abstracts). 2009, 69(24 Suppl):Abstract nr 5104.

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