SBC-110736( SBC-110736 | SBC 110736 | SBC110736 )

Catalog No. M17349 CAS No. 1629166-02-4

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Datasheet

HNMR

HPLC

MSDS

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Product Name

SBC-110736
Note

Research use only, not for human use.
Brief Description

SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor.
Description

SBC-110736 is a novel inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9), and has been shown to lower cholesterol levels in mice.
In Vitro

——
In Vivo

SBC-110736 (male C57BL/6 mice) lowers cholesterol levels in mice that were fed high fat diet, showing a mean of 38% reduction in total cholesterol levels after two weeks relative to high fat diet animal levels and a mean 50% reduction toward return to regular diet cholesterol levels.
Synonyms

SBC-110736 | SBC 110736 | SBC110736
Pathway

Neuroscience
Target

GluR
Recptor

PCSK9
Research Area

Cardiovascular Disease
Indication

——

CAS Number

1629166-02-4
Formula Weight

413.51
Molecular Formula

C26H27N3O2
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 100 mg/mL. 241.83 mM
SMILES

O=C(c1ccc(NC(C)=O)cc1)N3CCN(CC3c2ccccc2)c4ccc(C)cc4
Chemical Name

N-[4-(2-Phenyl-4-p-tolyl-piperazine-1-carbonyl)-phenyl]-acetamide

1. WO2014150395A1

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