ML221( ML221 | ML 221 | ML-221 )

Catalog No. M17640 CAS No. 877636-42-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ML221
Note

Research use only, not for human use.
Brief Description

ML221 is a potent apelin /APJ functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays.
Description

ML221 is a potent apelin /APJ functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays.
In Vitro

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In Vivo

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Synonyms

ML221 | ML 221 | ML-221
Pathway

Others
Target

Other Targets
Recptor

APJ
Research Area

Neurological Disease
Indication

——

CAS Number

877636-42-5
Formula Weight

385.35
Molecular Formula

C17H11N3O6S
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 31 mg/mL; 80.45 mM
SMILES

C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)[N+](=O)[O-]
Chemical Name

[4-oxo-6-(pyrimidin-2-ylsulfanylmethyl)pyran-3-yl] 4-nitrobenzoate

1. Maloney PR, etal.Bioorg Med Chem Lett. 2012 Nov 1;22(21):6656-60.

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