AS 602801( AS602801 | PGL-5001 | PGL 5001 | Bentamapimod )

Catalog No. M17611 CAS No. 848344-36-5

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Product Name

AS 602801
Note

Research use only, not for human use.
Brief Description

AS 602801(Bentamapimod) is a novel, orally active inhibitor of JNK.
Description

Bentamapimod, also known as AS602801 and PGL5001, is a JNK Inhibitor. AS602801 induces regression of endometriotic lesions in animal models. AS602801 interrupts immune pathways. Bentamapimod induced regression of endometriotic lesions in endometriosis rodent animal models without suppressing ER action. Endometriosis is an estrogen (ER)-dependent gynecological disease caused by the growth of endometrial tissue at extrauterine sites.
In Vitro

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In Vivo

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Synonyms

AS602801 | PGL-5001 | PGL 5001 | Bentamapimod
Pathway

Others
Target

Other Targets
Recptor

JNK1| JNK2| JNK3
Research Area

Inflammation/Immunology
Indication

——

CAS Number

848344-36-5
Formula Weight

457.55
Molecular Formula

C25H23N5O2S
Purity

>98% (HPLC)
Solubility

DMSO : 14.29 mg/mL. 31.23 mM;
SMILES

N#CC(c1nc2ccccc2s1)c1nc(OCc2ccc(CN3CCOCC3)cc2)ncc1
Chemical Name

2-(1,3-benzothiazol-2-yl)-2-[2-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)pyrimidin-4-yl]acetonitrile

1. Ferrandi C, et al. Mult Scler. 2011 Jan;17(1):43-56.

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