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NSC 207895

CAS No. 58131-57-0

NSC 207895( —— )

Catalog No. M17547 CAS No. 58131-57-0

NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	110	In Stock
2MG	70	In Stock
5MG	116	In Stock
10MG	187	In Stock
25MG	432	In Stock
50MG	625	In Stock
100MG	889	In Stock
200MG	Get Quote	In Stock
500MG	1786	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

NSC 207895
Note

Research use only, not for human use.
Brief Description

NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
Description

NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
In Vitro

Western Blot Analysis Cell Line:RAW 264.7 cells.Concentration:0.5 μM.Incubation Time:30 min (stimulated with LPS (100 ng/ml) for 6 h).Result:Upregulated p53 protein levels.
In Vivo

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Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

P450
Recptor

p53 , MDMX
Research Area

——
Indication

——

Chemical Information

CAS Number

58131-57-0
Formula Weight

279.25
Molecular Formula

C11H13N5O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 31.25 mg/mL (111.91 mM)
SMILES

CN1CCN(CC1)C2=CC=C(C3=NO[N+](=C23)[O-])[N+](=O)[O-]
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Wang H, et al. Mol Cancer Ther, 2011, 10(1), 69-79.

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