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IMR-1
CAS No. 310456-65-6
IMR-1( IMR-1 | IMR 1 | IMR1. Inhibitor of Mastermind Recruitment-1 )
Catalog No. M17472 CAS No. 310456-65-6
IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 50 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 46 | In Stock |
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| 25MG | 98 | In Stock |
|
| 50MG | 174 | In Stock |
|
| 100MG | 286 | In Stock |
|
| 200MG | 414 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIMR-1
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NoteResearch use only, not for human use.
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Brief DescriptionIMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
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DescriptionIMR-1 is a Mastermind Recruitment inhibitor. IMR-1 disrupted the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex on chromatin, thereby attenuating Notch target gene transcription. IMR-1 inhibited the growth of Notch-dependent cell lines and significantly abrogated the growth of patient-derived tumor xenografts.
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In Vitro——
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In VivoAnimal Model:Nude mouses with adenocarcinoma xenograft.Dosage:15mg/kg Administration:I.p.; for 28 days Result:Blocks tumor establishment.
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SynonymsIMR-1 | IMR 1 | IMR1. Inhibitor of Mastermind Recruitment-1
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PathwayOthers
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TargetOther Targets
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RecptorNotch
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number310456-65-6
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Formula Weight353.41
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Molecular FormulaC15H15NO5S2
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 100 mg/mL 282.96 mM; H2O : < 0.1 mg/mL
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SMILESC(=O)(COc1c(cc(cc1)/C=C/1\SC(=S)NC1=O)OC)OCC
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Chemical Name(E)-Ethyl 2-(2-methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Astudillo L, et al. Cancer Res. 2016, 76(12):3593-603.
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