IMR-1( IMR-1 | IMR 1 | IMR1. Inhibitor of Mastermind Recruitment-1 )

Catalog No. M17472 CAS No. 310456-65-6

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Datasheet

HNMR

HPLC

MSDS

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Product Name

IMR-1
Note

Research use only, not for human use.
Brief Description

IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
Description

IMR-1 is a Mastermind Recruitment inhibitor. IMR-1 disrupted the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex on chromatin, thereby attenuating Notch target gene transcription. IMR-1 inhibited the growth of Notch-dependent cell lines and significantly abrogated the growth of patient-derived tumor xenografts.
In Vitro

——
In Vivo

Animal Model:Nude mouses with adenocarcinoma xenograft.Dosage:15mg/kg Administration:I.p.; for 28 days Result:Blocks tumor establishment.
Synonyms

IMR-1 | IMR 1 | IMR1. Inhibitor of Mastermind Recruitment-1
Pathway

Others
Target

Other Targets
Recptor

Notch
Research Area

Cancer
Indication

——

CAS Number

310456-65-6
Formula Weight

353.41
Molecular Formula

C15H15NO5S2
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 100 mg/mL 282.96 mM; H2O : < 0.1 mg/mL
SMILES

C(=O)(COc1c(cc(cc1)/C=C/1\SC(=S)NC1=O)OC)OCC
Chemical Name

(E)-Ethyl 2-(2-methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetate

1.Astudillo L, et al. Cancer Res. 2016, 76(12):3593-603.

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