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Desfesoterodine
CAS No. 207679-81-0
Desfesoterodine( PNU-200577 | (R)-5-Hydroxymethyl Tolterodine )
Catalog No. M17424 CAS No. 207679-81-0
5-hydroxymethyl tolterodine (PNU 200577) is a new muscarinic receptor antagonist with Kb of 0.84 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 132 | In Stock |
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| 10MG | 205 | In Stock |
|
| 25MG | 353 | In Stock |
|
| 50MG | 520 | In Stock |
|
| 100MG | 750 | In Stock |
|
| 500MG | 1521 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDesfesoterodine
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NoteResearch use only, not for human use.
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Brief Description5-hydroxymethyl tolterodine (PNU 200577) is a new muscarinic receptor antagonist with Kb of 0.84 nM.
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Description5-hydroxymethyl tolterodine (PNU 200577) is a new muscarinic receptor antagonist with Kb of 0.84 nM.
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In VitroIn vitro, Desfesoterodine preventes carbachol-induced contraction of guinea-pig isolated urinary bladder strips in a competitive and concentration-dependent manner. In radioligand binding studies carries out in homogenates of guinea-pig tissues and Chinese hamster ovary cell lines expressing human muscarinic m1-m5 receptors, Desfesoterodine is not selective for any muscarinic receptor subtype.
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In VivoDesfesoterodine (PNU-200577; 5-Hydroxymethyl Tolterodine; 0.1 and 1 mg/kg; IV) significantly increases bladder compliance after moderate and high doses. In vivo, Desfesoterodine is significantly more potent at suppressing acetylcholine-induced urinary bladder contraction than electrically induced salivation in the anaesthetised cat (ID50=15 and 40 nmol/kg, respectively) . Animal Model:Female Sprague Dawley rats at ages 9 to 11 weeks weighing 180 to 250 gDosage:0.1 and 1 mg/kg Administration:IV; single imidafenacin administration Result:Significantly increased bladder compliance after moderate and high doses.
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SynonymsPNU-200577 | (R)-5-Hydroxymethyl Tolterodine
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PathwayMetabolic Enzyme/Protease
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TargetPhosphatase
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RecptormAChR
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number207679-81-0
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Formula Weight341.49
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Molecular FormulaC22H31NO2
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 100 mg/mL; 292.83 mM
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SMILESCC(C)N(CC[C@H](C1=CC=CC=C1)C1=C(O)C=CC(CO)=C1)C(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nilvebrant L, et al. Pharmacol Toxicol, 1997, 81(4), 169-172.
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