Cart
sales@molnova.com
PD168393
CAS No. 194423-15-9
PD168393( PD168393 | PD 168393 | PD-168393 )
Catalog No. M17409 CAS No. 194423-15-9
PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 48 | In Stock |
|
| 2MG | 43 | In Stock |
|
| 5MG | 58 | In Stock |
|
| 10MG | 86 | In Stock |
|
| 25MG | 149 | In Stock |
|
| 50MG | 218 | In Stock |
|
| 100MG | 304 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePD168393
-
NoteResearch use only, not for human use.
-
Brief DescriptionPD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.
-
DescriptionPD-168393 is a potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM).
-
In VitroPD168393 inhibits ligand-dependent receptor phosphorylation and?inhibits EGF-induced tyrosine phosphorylation in A431 cells and Heregulin-induced tyrosine phosphorylation in MDA-MB-453 cells with IC50 values of 4.3? nM and 5.7? nM, respectively.
-
In VivoPD168393 (intraperitoneal injection; 58 mg/kg; once daily; days 10-14, 17-21, and 24-28) is effective?in vivo, and produces tumor growth inhibition of 115% after 15 days’ treatment in human epidermoid carcinoma xenografts in mice. Animal Model:A431 human epidermoid carcinoma grown as a xenograft in nude mice Dosage:58 mg/kg Administration:Intraperitoneal injection; 58 mg/kg; once daily; days 10-14, 17-21, and 24-28 Result:Suppressed the growth of human epidermoid carcinoma xenografts.
-
SynonymsPD168393 | PD 168393 | PD-168393
-
PathwayNeuroscience
-
TargetGluR
-
RecptorEGFR| FGFR| Insulin Receptor| PDGFR| PKC
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number194423-15-9
-
Formula Weight369.22
-
Molecular FormulaC17H13BrN4O
-
Purity>98% (HPLC)
-
SolubilityDMSO : ≥ 30 mg/mL. 81.25 mM
-
SMILESC=CC(=O)Nc1cc2c(cc1)ncnc2Nc1cc(ccc1)Br
-
Chemical Name4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Fry DW,et al. Specific, Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):12022-7.
molnova catalog
related products
-
Valiglurax
Valiglurax (VU2957), also known as VU0652957 and VU2957, is a potent, selective, CNS penetrant, and orally bioavailable mGlu4 PAM. VU2957 possessed attractive in vitro and in vivo pharmacological and DMPK properties across species.
-
CDPPB
CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5).
-
S 18986
S 18986 is a selective, orally active, brain-penetrant positive allosteric modulator of AMPA-type receptors that enhances cognition in rodents by inducing the release of noradrenaline and acetylcholine in the rat hippocampus, subsequently improving object-recognition memory.
