Cart
sales@molnova.com
SGC2085 HCl
CAS No. 1821908-49-9
SGC2085 HCl( —— )
Catalog No. M17389 CAS No. 1821908-49-9
SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 138 | In Stock |
|
| 5MG | 180 | In Stock |
|
| 10MG | 325 | In Stock |
|
| 25MG | 537 | In Stock |
|
| 50MG | 781 | In Stock |
|
| 100MG | 1071 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSGC2085 HCl
-
NoteResearch use only, not for human use.
-
Brief DescriptionSGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs.
-
DescriptionSGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. CARM1 is an important positive modulator of Wnt/β-catenin transcription and neoplastic transformation in colorectal cancer as well as a critical factor in estrogen-stimulated breast cancer growth, and its depletion results in decreased proliferation of myeloid leukemia cells in vivo.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayChromatin/Epigenetic
-
TargetEpigenetic Reader Domain
-
RecptorCoactivator Associated Arginine Methyltransferase 1 (CARM1)
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1821908-49-9
-
Formula Weight348.87
-
Molecular FormulaC19H24N2O2·HCl
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC(=O)([C@H](C)N)NCc1cc(c(cc1)Oc1cc(cc(c1)C)C)C.Cl
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Renato., et al. Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening . J Med Chem. 2016 Jul 28;59(14):6838-47.
molnova catalog
related products
-
Escitalopram Oxalate
Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.
-
BRD7-IN-1
BRD7-IN-1, a modified derivative of BI7273 (BRD7/9 inhibitor), forms PROTAC VZ185 via linkage to a VHL ligand, demonstrating potent activity against BRD7/9 with DC50 values of 4.5 and 1.8 nM, respectively .
-
dBRD9 HCl
dBRD9 HCl is a PROTAC composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide . dBRD9 HCl is a potent and selective degrader of BRD9 (IC50 = 56.6 nM in MOLM-13 cells).
