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Nolatrexed dihydrochloride
CAS No. 152946-68-4
Nolatrexed dihydrochloride( AG 337 | Thymitaq )
Catalog No. M17332 CAS No. 152946-68-4
Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 37 | In Stock |
|
| 5MG | 42 | In Stock |
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| 10MG | 69 | In Stock |
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| 25MG | 140 | In Stock |
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| 50MG | 213 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNolatrexed dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionNolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity.
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DescriptionNolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.
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In Vitro——
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In Vivo——
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SynonymsAG 337 | Thymitaq
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PathwayOthers
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TargetOther Targets
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RecptorThymidylate synthase
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Research Area——
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Indication——
Chemical Information
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CAS Number152946-68-4
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Formula Weight357.26
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Molecular FormulaC14H14Cl2N4OS
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Purity>98% (HPLC)
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SolubilityDMSO : 41.67 mg/mL. 116.64 mM;
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SMILESCc1c(c2c(cc1)[nH]c(N)nc2=O)Sc1ccncc1.Cl.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hughes AN, et al. Br J Y. 2000 May;82(9):1519-27.
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