Nolatrexed dihydrochloride
CAS No. 152946-68-4
Nolatrexed dihydrochloride( AG 337 | Thymitaq )
Catalog No. M17332 CAS No. 152946-68-4
Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 37 | In Stock |
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| 5MG | 42 | In Stock |
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| 10MG | 69 | In Stock |
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| 25MG | 140 | In Stock |
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| 50MG | 213 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNolatrexed dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionNolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity.
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DescriptionNolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.
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In Vitro——
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In Vivo——
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SynonymsAG 337 | Thymitaq
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PathwayOthers
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TargetOther Targets
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RecptorThymidylate synthase
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Research Area——
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Indication——
Chemical Information
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CAS Number152946-68-4
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Formula Weight357.26
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Molecular FormulaC14H14Cl2N4OS
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Purity>98% (HPLC)
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SolubilityDMSO : 41.67 mg/mL. 116.64 mM;
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SMILESCc1c(c2c(cc1)[nH]c(N)nc2=O)Sc1ccncc1.Cl.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Mitoquidone
Mitoquidone, a novel pentacyclic pyrroloquinone, is a potential anticancer agent. Mitoquidone showed good activity in a range of experimental solid tumour models and did not exhibit significant cytotoxicity.
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Harmidol hydrochlori...
Harmalol hydrochloride is a β-carboline alkaloid that can be extracted from the seeds of Peganum harmala L. Harmalol hydrochloride is the major metabolite of Harmaline and significantly inhibits dioxin-mediated induction of CYP1A1 at both transcriptional and post-translational levels.
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