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NSC5844

CAS No. 140926-75-6

NSC5844( NSC5844 | NSC-5844 | NSC 5844 | RE640 )

Catalog No. M17281 CAS No. 140926-75-6

NSC5844 (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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100MG 291 Get Quote
200MG 435 Get Quote
500MG 698 Get Quote
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Biological Information

  • Product Name
    NSC5844
  • Note
    Research use only, not for human use.
  • Brief Description
    NSC5844 (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.
  • Description
    NSC5844, also known as RE640, is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic properties.
  • In Vitro
    NSC5844 (Compound 10) is a 4-aminoquinoline derivative, and has antitumor activity with GI50s of 7.35 ± 0.10 μM and 14.80 ± 0.35 μM against MDA-MB-468 and MCF-7 cells, respectively. NSC5844 (Compound 1) is cytotoxic to P. falciparum, inhibits the growth of chloroquine-sensitive (D-6) and -resistant (W-2) clones of P. falciparum, with IC50s of 17 and 27 nM, respectively.
  • In Vivo
    ——
  • Synonyms
    NSC5844 | NSC-5844 | NSC 5844 | RE640
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PI3K
  • Recptor
    CCR1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    140926-75-6
  • Formula Weight
    383.27
  • Molecular Formula
    C20H16Cl2N4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 1 mg/mL (2.61 mM)
  • SMILES
    c1cc2c(ccnc2cc1Cl)NCCNc1c2ccc(cc2ncc1)Cl
  • Chemical Name
    N,N'-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhang H, et al. Biomed PharmacOthers. 2008 Feb;62(2):65-9.
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