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PF-04979064
CAS No. 1220699-06-8
PF-04979064( PF 04979064 | PF04979064 )
Catalog No. M10834 CAS No. 1220699-06-8
A highly potent and selective, dual PI3K/mTOR inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 32 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 50 | In Stock |
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| 25MG | 102 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePF-04979064
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NoteResearch use only, not for human use.
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Brief DescriptionA highly potent and selective, dual PI3K/mTOR inhibitor.
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DescriptionA highly potent and selective, dual PI3K/mTOR inhibitor with Ki of 0.13, 0.111, 0.122 and 1.42 nM for PI3Kα, PI3Kγ, PI3Kδ and mTOR, respectively; exhibits excellent in vitro potency, very good solubility, high LipE, excellent kinome selectivity, robust PK/PD correlation and TGI efficacy, and acceptable predicted human clearance after incorporating both CYP- and AO-mediated metabolism.
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In VitroPF-04979064 is tested against human class I PI3K isoforms PI3Kα, PI3Kγ, and PI3Kδ, with PI3Kα Ki of 0.13 nM, PI3Kγ Ki of 0.111 nM, and PI3Kδ Ki of 0.122 nM.
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In VivoPF-04979064 is progressed to rat in vivo PK studies and exhibits robust PK profile: Vdss=5.23 L/kg, Cl=19.3 mL/min/kg, T1/2=1.85 h, and F%=61%.
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SynonymsPF 04979064 | PF04979064
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3K
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1220699-06-8
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Formula Weight446.5016
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Molecular FormulaC24H26N6O3
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Purity>98% (HPLC)
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SolubilityDMSO: 11 mg/mL
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SMILESCC1=NC=C(C=C1)C2=NC3=C4C(=CN=C3C=C2)N(C(=O)N4C5CCN(CC5)C(=O)C(C)O)C
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Chemical Name2H-Imidazo[4,5-c][1,5]naphthyridin-2-one, 1,3-dihydro-1-[1-[(2S)-2-hydroxy-1-oxopropyl]-4-piperidinyl]-3-methyl-8-(6-methyl-3-pyridinyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cheng H, et al. ACS Med Chem Lett. 2012 Nov 7;4(1):91-7.
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