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BPR1J-097
CAS No. 1327167-19-0
BPR1J-097( BPR1J097 | BPR1J-097 | BPR1J 097 )
Catalog No. M17246 CAS No. 1327167-19-0
BPR1J-097 is a novel FLT-3 inhibitor(IC50: 11±7 nM) with promising in vivo anti-tumor activities. It also inhibits FLT-3 D835Y (IC50: 3 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 113 | In Stock |
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| 2MG | 48 | In Stock |
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| 5MG | 60 | In Stock |
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| 10MG | 103 | In Stock |
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| 25MG | 225 | In Stock |
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| 50MG | 377 | In Stock |
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| 100MG | 544 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBPR1J-097
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NoteResearch use only, not for human use.
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Brief DescriptionBPR1J-097 is a novel FLT-3 inhibitor(IC50: 11±7 nM) with promising in vivo anti-tumor activities. It also inhibits FLT-3 D835Y (IC50: 3 nM).
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DescriptionBPR1J-097 is a novel small molecule FLT-3 inhibitor with promising in vivo anti-tumour activities. BPR1J-097 may be useful in AML treatments.IC50 of BPR1J-097 required to inhibit FLT3 kinase activity ranged from 1 to 10 nM, and the 50% growth inhibition concentrations (GC(50)s) were 21 ±7 and 46 ±14 nM for MOLM-13 and MV4-11 cells, respectively. BPR1J-097 inhibited FLT3/signal transducer and activator of transcription 5 phosphorylation and triggered apoptosis in FLT3-driven AML cells. BPR1J-097 also showed favourable pharmacokinetic property and pronounced dose-dependent tumour growth inhibition and regression in FLT3-driven AML murine xenograft models.
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In Vitro——
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In Vivo——
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SynonymsBPR1J097 | BPR1J-097 | BPR1J 097
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PathwayAngiogenesis
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TargetEGFR
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RecptorFLT3
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1327167-19-0
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Formula Weight516.62
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Molecular FormulaC27H28N6O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESCN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c(c1)c1cc(ccc1)NS(=O)(=O)c1ccccc1
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Chemical Name4-(4-methylpiperazin-1-yl)-N-(3-(3-(phenylsulfonamido)phenyl)-1H-pyrazol-5-yl)benzamide.
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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GSK-LSD1 dihydrochlo...
GSK-LSD1 2HCl is a specificity irreversible LSD1 inhibitor (IC50: 16 nM). The selectivity of GSK-LSD1 for LSD1 is >1000 fold over other closely related FAD utilizing enzymes (i.e. MAO-A, LSD2, MAO-B).
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AV-412
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